Phenotypes associated with this allele

• Allele Symbol: Ret^tm1Cti
• Allele Name: targeted mutation 1, Cristiana Carniti
• Allele ID: MGI:3626295
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ret^tm1Cti/Ret^tm1Cti	involves: 129S/SvEv * C57BL/6J	MGI:3628454
ht2	Ret^tm1Cti/Ret^+	involves: 129S/SvEv * C57BL/6J	MGI:3628455

Genotype
MGI:3628454

hm1

• Allelic Composition: Ret^tm1Cti/Ret^tm1Cti
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:107335 )

• homozygotes are born alive, respond to tail pinch and nurse normally, but all die within 24 hours of birth

nervous system

abnormal enteric ganglia morphology ( J:107335 )

• enteric ganglion cells are absent from the stomach and small and large bowel of homozygotes

absent enteric neurons ( J:107335 )

• no enteric neurons are found in the foregut, midgut or hindgut

renal/urinary system

absent kidney ( J:107335 )

• homozygotes demonstrate agenesis of the kidneys and lack both kidneys

abnormal urinary bladder morphology ( J:107335 )

• homozygous newborns have empty bladders

Genotype
MGI:3628455

ht2

• Allelic Composition: Ret^tm1Cti/Ret⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6J

nervous system

abnormal enteric neuron morphology ( J:107335 )

• male heterozygotes have a lower number of enteric neurons in the stomach, duodenum, jejunum, ileum, cecum and in colon; female heterozygotes display the same features in the duodenum, ileum, cecum and in both the proximal and distal part of the colon

digestive/alimentary system

abnormal large intestine morphology ( J:107335 )

• in both male and female heterozygotes, the muscular layer of proximal and distal colon is thinner than in wild-type; in females the apex of the cecum shows reduced muscle thickness, while males show a thinner muscular layer in the body and apex of the cecum

abnormal small intestine morphology ( J:107335 )

• a reduced thickness of the muscular layer of the duodenum of heterozygotes is apparent; female heterozygotes display reduced muscle thickness in the jejunum