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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il23atm1Gdy
targeted mutation 1, George D Yancopoulos
MGI:3625894
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il23atm1Gdy/Il23atm1Gdy B6.Cg-Il23atm1Gdy MGI:3810264
ht2
 		Il23atm1Gdy/Il23a+ B6.Cg-Il23atm1Gdy MGI:3810265


Genotype
MGI:3810264
hm1
Allelic
Composition		 Il23atm1Gdy/Il23atm1Gdy
Genetic
Background		 B6.Cg-Il23atm1Gdy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23atm1Gdy mutation (0 available); any Il23a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:139557 )
• following induction of colitis with TNBS, mice exhibit increased colitis-associated lethality compared to in wild-type mice
• however, inhibition of IL12b with antibodies rescues mice from lethal colitis

immune system
increased susceptibility to induced colitis ( J:139557 )
• following induction of colitis with DSS or TNBS, mice exhibit increased weight loss and more severe colitis with epithelial erosion and massive infiltration compared to wild-type mice
• following induction of colitis with TNBS, mice exhibit increased colitis-associated lethality comapred to in wild-type mice
• however, inhibition of IL12b with antibodies rescues mice from lethal colitis

digestive/alimentary system
increased susceptibility to induced colitis ( J:139557 )
• following induction of colitis with DSS or TNBS, mice exhibit increased weight loss and more severe colitis with epithelial erosion and massive infiltration compared to wild-type mice
• following induction of colitis with TNBS, mice exhibit increased colitis-associated lethality comapred to in wild-type mice
• however, inhibition of IL12b with antibodies rescues mice from lethal colitis

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:139557 )
• following induction of colitis with TNBS, mice exhibit increased colitis-associated lethality compared to in wild-type mice
• however, inhibition of IL12b with antibodies rescues mice from lethal colitis




Genotype
MGI:3810265
ht2
Allelic
Composition		 Il23atm1Gdy/Il23a+
Genetic
Background		 B6.Cg-Il23atm1Gdy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il23atm1Gdy mutation (0 available); any Il23a mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to induced colitis ( J:139557 )
• following induction of colitis with DSS, mice exhibit increased weight loss compared to wild-type mice

digestive/alimentary system
increased susceptibility to induced colitis ( J:139557 )
• following induction of colitis with DSS, mice exhibit increased weight loss compared to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory