Phenotypes associated with this allele

• Allele Symbol: Nnt^N68K
• Allele Name: N68K
• Allele ID: MGI:3625821
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nnt^N68K/Nnt^N68K	involves: BALB/c * C3H/HeH	MGI:3625834

Genotype
MGI:3625834

hm1

• Allelic Composition: Nnt^N68K/Nnt^N68K
• Genetic Background: involves: BALB/c * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:108421 )

N • no defects in thermoregulation are seen

decreased insulin secretion ( J:108421 )

• secrete less insulin following glucose challenge

impaired glucose tolerance ( J:108421 )

• observed at 12 and 16 weeks of age; also seen in heterozygous mice but is less severe

cellular

abnormal cell physiology ( J:108421 )

• unlike controls, no increase in ATP content in islets is detectable with increased glucose concentration

• glucose induces a dramatic increase in reactive oxygen species in beta cells compared to controls

• glucose utilization is greater in mutant islets than in controls

endocrine/exocrine glands

decreased insulin secretion ( J:108421 )

• secrete less insulin following glucose challenge