Analysis Tools
normal phenotype
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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Allele Symbol Allele Name Allele ID |
Sox2tm4Lpev targeted mutation 4, Larysa H Pevny MGI:3625178 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• show hypoplasia of optic nerves and chiasmata by gross morphological analyses of brain
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• a range of eye phenotypes from mild bilateral microphthalmia to severe anophthalmia
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• disrupted cell layering consisting of rosette structures
• retinal ganglion cells are inappropriately localized
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• 30%-40% thinner than wild-type retinas
• reduction in cell number
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• a range of eye phenotypes from mild bilateral microphthalmia to severe anophthalmia
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• show hypoplasia of optic nerves and chiasmata by gross morphological analyses of brain
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E13.5-E16.5, embryos display microphthalmia of variable severity
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• at E14.75, palatal shelves are abnormally separated, with consistently unilateral defects in the anterior third of the palatal shelf
• at E16.5, a broad cleft is present, unlike in control fetuses where palatal shelf fusion is complete
• however, developing secondary palatal shelves are normal at E13.5, and no mandibular hypoplasia/retrognathia is noted at E16.5
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• 67% of newborns exhibit secondary palatal clefting
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• at E14.75, all embryos with clefting (5/5) also display a unilateral failure of shelf elevation, either specifically in the anterior region (4/5) or along the length of the secondary palate (1/5)
• however, by E16.5, most of the affected embryos show bilaterally elevated palatal shelves
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• at E16.5, a subset of embryos exhibit asymmetry of the palatal shelves
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• at E14.75, palatal shelves are abnormally separated, with consistently unilateral defects in the anterior third of the palatal shelf
• at E16.5, a broad cleft is present, unlike in control fetuses where palatal shelf fusion is complete
• however, developing secondary palatal shelves are normal at E13.5, and no mandibular hypoplasia/retrognathia is noted at E16.5
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• 67% of newborns exhibit secondary palatal clefting
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• at E14.75, all embryos with clefting (5/5) also display a unilateral failure of shelf elevation, either specifically in the anterior region (4/5) or along the length of the secondary palate (1/5)
• however, by E16.5, most of the affected embryos show bilaterally elevated palatal shelves
|
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• at E16.5, a subset of embryos exhibit asymmetry of the palatal shelves
|
|
• at E14.75, palatal shelves are abnormally separated, with consistently unilateral defects in the anterior third of the palatal shelf
• at E16.5, a broad cleft is present, unlike in control fetuses where palatal shelf fusion is complete
• however, developing secondary palatal shelves are normal at E13.5, and no mandibular hypoplasia/retrognathia is noted at E16.5
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• 67% of newborns exhibit secondary palatal clefting
|
|
• at E14.75, all embryos with clefting (5/5) also display a unilateral failure of shelf elevation, either specifically in the anterior region (4/5) or along the length of the secondary palate (1/5)
• however, by E16.5, most of the affected embryos show bilaterally elevated palatal shelves
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• at E16.5, a subset of embryos exhibit asymmetry of the palatal shelves
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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