Analysis Tools
normal phenotype
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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Allele Symbol Allele Name Allele ID |
Sox2tm3Lpev targeted mutation 3, Larysa H Pevny MGI:3625177 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pups die shortly after birth
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• a range of eye phenotypes from mild bilateral microphthalmia to severe anophthalmia
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• disrupted cell layering consisting of rosette structures
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• 30%-40% thinner than wild-type retinas
• reduction in cell number
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| N |
• no defects in sensory innervation of the tongue are apparent
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• taste buds are absent in the mutant palate at P0
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• no defects in the initial number, morphology or distribution of fungiform papillae
• by E16.5-18.5, fewer fungiform papillae are present compared to controls
• from E14.5-E18, a gradual reduction in the size and morphology of the fungiform papillae is seen
• fungiform taste buds, detected by keratin 8 immunostaining, are absent in P0 mutant tongues
• no abnormalities are seen in the filiform papillae at any stage
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• taste buds are absent in the mutant palate at P0
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• no defects in the initial number, morphology or distribution of fungiform papillae
• by E16.5-18.5, fewer fungiform papillae are present compared to controls
• from E14.5-E18, a gradual reduction in the size and morphology of the fungiform papillae is seen
• fungiform taste buds, detected by keratin 8 immunostaining, are absent in P0 mutant tongues
• no abnormalities are seen in the filiform papillae at any stage
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• taste buds are absent in the mutant palate at P0
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• no defects in the initial number, morphology or distribution of fungiform papillae
• by E16.5-18.5, fewer fungiform papillae are present compared to controls
• from E14.5-E18, a gradual reduction in the size and morphology of the fungiform papillae is seen
• fungiform taste buds, detected by keratin 8 immunostaining, are absent in P0 mutant tongues
• no abnormalities are seen in the filiform papillae at any stage
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• taste buds are absent in the mutant palate at P0
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P0, mice die with air in their stomachs
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| N |
• despite respiratory distress and air in their stomachs, mice do not exhibit even a small tracheoesophageal fistula
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• the esophagus is thinner than in wild-type mice and not squamous
• unlike in wild-type mice, esophageal tissue stains positive for mucus production markers
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• the esophagus is thinner than in wild-type mice and not squamous
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• mice lack serous- and mucous-secreting glands in the posterior tongue and soft palate
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• while the circumvallate papilla is present, Ebner's glands are not branched
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• unlike in wild-type mice, the anterior stomach acquires posterior characteristics such as reduced keratinization, ectopic mucus cells and columnar epithelium
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• the epiglottis is abnormally positioned relative to the soft palate
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| N |
• despite respiratory distress and air in their stomachs, mice do not exhibit even a small tracheoesophageal fistula
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• the epiglottis is abnormally positioned relative to the soft palate
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• at P0, mice exhibit labored breathing
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• the epiglottis is abnormally positioned relative to the soft palate
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• mice lack serous- and mucous-secreting glands in the posterior tongue and soft palate
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• while the circumvallate papilla is present, Ebner's glands are not branched
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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