All Phenotypes Sox2<tm2.1Lpev> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox2^tm2.1Lpev
targeted mutation 2.1, Larysa H Pevny
MGI:3625176

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox2^tm2Lpev/Sox2^tm2.1Lpev Tg(Pax6-cre,GFP)2Pgr/?	involves: 129S/SvEv	MGI:3713886

Allelic Composition	Sox2^tm2Lpev/Sox2^tm2.1Lpev Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm2.1Lpev mutation (0 available); any Sox2 mutation (56 available)
Sox2^tm2Lpev mutation (1 available); any Sox2 mutation (56 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:108452 )

• at E13.5, retinas are significantly smaller than Sox2^tm2Lpev Tg(Pax6-cre,GFP)2Pgr heterozygotes

• retinal proliferation is reduced and differentiation marked by Math5, NeuroD, and beta-TubulinIII staining is absent

retina hypoplasia ( J:108452 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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