Analysis Tools
normal phenotype
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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Allele Symbol Allele Name Allele ID |
Sox2tm2Lpev targeted mutation 2, Larysa H Pevny MGI:3625175 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable, born in appropriate Mendelian ratios, phenotypically and morphologically indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P0, mice die with air in their stomachs
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• in some mice parts of the esophagus are thin or absent
• in mice without a tracheoesophageal fistula the esophagus is thinner than in wild-type mice and not squamous
• unlike in wild-type mice, esophageal tissue stains positive for mucus production markers
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• in mice without a tracheoesophageal fistula the esophagus is thinner than in wild-type mice and not squamous
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• in 60% of mice
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• in 60% of mice, a dorsally located fistula, known as the distal esophagus, connects the undivided foregut/trachea with a tube leading to the stomach
• at E18.5, the fistula is composed of simple columnar epithelium that resembles normal trachea epithelium with some multilayered regions
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• unlike in wild-type mice, the anterior stomach acquires posterior characteristics such as reduced keratinization, ectopic mucus cells and columnar epithelium
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• BrdU incorporation of fistula esophageal epithelium is 7% of the rate observed in heterozygote controls and is similar to the proliferation rates observed in wild-type tracheal cells
• in mice without a tracheoesophageal fistula proliferating cells are found within the suprabasal layers of the esophageal epithelium compared to in the basal layers of stratified epithelium in control Sox2tm2Lpev heterozygotes
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• in 60% of mice, a dorsally located fistula, known as the distal esophagus, connects the undivided foregut/trachea with a tube leading to the stomach
• at E18.5, the fistula is composed of simple columnar epithelium that resembles normal trachea epithelium with some multilayered regions
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• at P0, mice exhibit labored breathing
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P0, mice die with air in their stomachs
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| N |
• despite respiratory distress and air in their stomachs, mice do not exhibit even a small tracheoesophageal fistula
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• the esophagus is thinner than in wild-type mice and not squamous
• unlike in wild-type mice, esophageal tissue stains positive for mucus production markers
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• the esophagus is thinner than in wild-type mice and not squamous
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• mice lack serous- and mucous-secreting glands in the posterior tongue and soft palate
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• while the circumvallate papilla is present, Ebner's glands are not branched
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• unlike in wild-type mice, the anterior stomach acquires posterior characteristics such as reduced keratinization, ectopic mucus cells and columnar epithelium
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• the epiglottis is abnormally positioned relative to the soft palate
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| N |
• despite respiratory distress and air in their stomachs, mice do not exhibit even a small tracheoesophageal fistula
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• the epiglottis is abnormally positioned relative to the soft palate
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• at P0, mice exhibit labored breathing
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• the epiglottis is abnormally positioned relative to the soft palate
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• mice lack serous- and mucous-secreting glands in the posterior tongue and soft palate
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• while the circumvallate papilla is present, Ebner's glands are not branched
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E13.5, retinas are significantly smaller than Sox2tm2Lpev Tg(Pax6-cre,GFP)2Pgr heterozygotes
• retinal proliferation is reduced and differentiation marked by Math5, NeuroD, and beta-TubulinIII staining is absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a further reduction in eye size at E14.5 compared to Sox2tm1Lpev/Sox2tm3Lpev or Sox2tm1Lpev/Sox2tm4Lpev hypomorphs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the loss of general retinal progenitor cell characteristics as determined by retinal differentiation makers
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• retinas are significantly smaller in size compared with Sox2tm2Lpev/Sox2+ with a transgene control
note: marked reduction of cell proliferation in the distal retina by E13.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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