Analysis Tools
homeostasis/metabolism
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• diabetic Ptprn-deficient mice and wild-type mice display insulitis
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Allele Symbol Allele Name Allele ID |
Ptprntm1Aln targeted mutation 1, Abner Louis Notkins MGI:3625093 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• diabetic Ptprn-deficient mice and wild-type mice display insulitis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 36.4% of NOD mice deficient for Ptprn develop diabetes as determined by 2 consecutive blood glucose levels above 250 mg/dl by 28 weeks of age while 44.4% of NOD wild-type mice develop diabetes
• 5 Ptprn-deficient mice show spontaneous diabetes between 20 and 40 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• double knockout male mice are fertile, unlike double mutant females; no alterations in testis histology or testis weight are observed at 12 weeks of age
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• lipid droplets are found in stromal cells at 7 weeks of age
• however, the number and appearance of oocytes and antral follicles is normal
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• corpora lutea are absent at 7 weeks and at 3 months of age
• however, large numbers of corpora lutea are formed within 96 h after PMSG + hCG treatment; hCG alone is not as effective as PMSG + hCG treatment
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• the typical LH surge required for ovulation is not observed at any of the times (i.e. daily) tested, unlike in wild-type controls
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• vaginal smears revealed total absence of a normal estrous cycle
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• double knockout females are essentially infertile, unlike single knockout females
• when mated with wild-type males, only 2 of 12 double knockout females produce offspring
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• when mated with wild-type males, only 2 of 12 double knockout females give birth and litter sizes are very small
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N |
• double knockout male mice show normal plasma LH and FSH levels at 4 months of age
• Western blot analysis revealed a non-significant (34%) reduction in the concentration of LH in pituitary lysates at 4 months of age
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• at 4 months of age, Western blot analysis revealed a 60% reduction in the concentration of FSH in pituitary lysates at proestrus
• however, basal FSH levels in the plasma are normal
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• at 4 months of age, Western blot analysis revealed a nearly 75% reduction in the concentration of LH in pituitary lysates at proestrus
• however, the concentration of LH is almost normal in pituitary lysates of pre-pubertal mice at 24 days of age
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• no typical LH surge is found in plasma during proestrus at 3-6 months of age, unlike in wild-type controls
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• lipid droplets are found in stromal cells at 7 weeks of age
• however, the number and appearance of oocytes and antral follicles is normal
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• corpora lutea are absent at 7 weeks and at 3 months of age
• however, large numbers of corpora lutea are formed within 96 h after PMSG + hCG treatment; hCG alone is not as effective as PMSG + hCG treatment
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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