Phenotypes associated with this allele

• Allele Symbol: Htr2a^tm1Rhn
• Allele Name: targeted mutation 1, Rene Hen
• Allele ID: MGI:3624812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Htr2a^tm1Rhn/Htr2a^tm1Rhn	involves: 129S1/Sv * C57BL/6	MGI:3625420

Genotype
MGI:3625420

hm1

• Allelic Composition: Htr2a^tm1Rhn/Htr2a^tm1Rhn
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal enterocyte morphology ( J:108058 )

• heights of enterocytes in the proximal and distal small intestine are lower in mutants compared to wild-type; cells are smaller both proximally and distally in mutants

decreased Paneth cell number ( J:108058 )

• in mutants, the density of Paneth cells (number/crypt) is significantly less than wild-type in both the proximal and distal small intestine

abnormal intestinal smooth muscle morphology ( J:108058 )

• in mutants, the bowel wall is thinner than in wild-type mice: thickness of the circular and longitudinal layers of muscle is less in proximal and distal small intestine of mutants due to presence of thinner muscle cells in mutants

• muscle cells of mutants appear to have fewer thin filaments

muscle

abnormal intestinal smooth muscle morphology ( J:108058 )

• in mutants, the bowel wall is thinner than in wild-type mice: thickness of the circular and longitudinal layers of muscle is less in proximal and distal small intestine of mutants due to presence of thinner muscle cells in mutants

• muscle cells of mutants appear to have fewer thin filaments

endocrine/exocrine glands

decreased Paneth cell number ( J:108058 )

• in mutants, the density of Paneth cells (number/crypt) is significantly less than wild-type in both the proximal and distal small intestine