Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etl4Gt(pU8)80211Imeg mutation
(0 available);
any
Etl4 mutation
(485 available)
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skeleton
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• layers of annulus fibrosus are thin
• failure of fibrous adhesion to vertebral bodies is observed
• phenotype is observed even in progeny backcrossed to C57BL/6 ten generations
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• dislocation of the nucleus pulposus is observed even in progeny backcrossed to C57BL/6 ten generations
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etl4Gt(pU8)80211Imeg mutation
(0 available);
any
Etl4 mutation
(485 available)
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skeleton
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• shortened and curved vertebrae are apparent at 2 weeks of age; this is restricted to caudal vertebrae 20 to 25
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• at E17.5, some intervertebral disks (IVDs) are compressed relative to wild-type, but at this age, size of IVDs are same as wild-type
• at 8 weeks, nucleus pulposus is dislocated to periphery of IVD in homozygotes with kinked and normal-appearing tails
• from caudal vertebrae 5 to 25, irregular boundary with direct contact between the nucleus pulposus the annulus fibrosus, compared to sharp boundary seen in wild-type
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• at 2 weeks, IVDs have disappeared due to nucleus pulposi abnormalities
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• at 2 weeks, nuclei pulposi are smaller and eccentric compared to wild-type
• at 8 weeks, nucleus pulposus of IVDs of tail region contains aggregation of notochord-like cells with paucity of vacuoles relative to wild-type; nucleus pulposus is dislocated to periphery of IVD
• in upper regions, appearance is normal
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• in 2 week-old mutants, nuclei pulposi are smaller and eccentric, resulting in disappearance of normal IVDs
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• in neonatal mice, alignment of vertebral bodies is undulated
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limbs/digits/tail
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• shortened and curved vertebrae are apparent at 2 weeks of age; this is restricted to caudal vertebrae 20 to 25
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• observed in 53% of homozygotes at 4 weeks
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etl4Gt(pU8)80211Imeg mutation
(0 available);
any
Etl4 mutation
(485 available)
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normal phenotype
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• animals appear normal, and are fertile
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etl4Gt(pU8)80211Imeg mutation
(0 available);
any
Etl4 mutation
(485 available)
Etn2Sd mutation
(3 available);
any
Etn2 mutation
(3 available)
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mortality/aging
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• mice die within 48 hours of birth
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limbs/digits/tail
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• neonates have shorter tails than compound heterozygotes
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skeleton
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• vertebral columns are truncated at ~fourth sacral vertebral body
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Allelic Composition |
Etl4Gt(pU8)80211Imeg/Etl4+ Etn2Sd/Etn2+
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Genetic Background |
involves: C57BL/6 * CBA * Danforth's duplication stock * STOCK Mcoln3Va |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etl4Gt(pU8)80211Imeg mutation
(0 available);
any
Etl4 mutation
(485 available)
Etn2Sd mutation
(3 available);
any
Etn2 mutation
(3 available)
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mortality/aging
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• all mice die within 2 weeks of birth
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embryo
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• by E13.5 notochord is fragmented in cis and trans compound heterozygotes
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• notochords of cis and trans compound heterozygotes are thin at E9.5
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limbs/digits/tail
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• both cis and trans compound heterozygotes have shorter tails
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skeleton
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• nucleus pulposus is completely absent and is replaced by peripheral fibers similar to those in annulus fibrosus in all intervertebral disks
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• vertebral column is truncated at the second and third caudal vertebral body in trans and cis compound mutants
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