All Phenotypes Coch<tm1.1Stw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Coch^tm1.1Stw
targeted mutation 1.1, Colin L Stewart
MGI:3624560

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Coch^tm1.1Stw/Coch^tm1.1Stw	CBACa.129S1-Coch^tm1.1Stw	MGI:4880749
hm2	Coch^tm1.1Stw/Coch^tm1.1Stw	involves: 129S1/Sv	MGI:3630341
hm3	Coch^tm1.1Stw/Coch^tm1.1Stw	involves: 129S1/Sv * C57BL/6 * CD-1	MGI:3700754
ht4	Coch^tm1.1Stw/Coch⁺	CBACa.129S1-Coch^tm1.1Stw	MGI:4880751

Allelic Composition	Coch^tm1.1Stw/Coch^tm1.1Stw
Genetic Background	CBACa.129S1-Coch^tm1.1Stw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coch^tm1.1Stw mutation (2 available); any Coch mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:167669 )

N	• despite hearing and vestibular deficits, no gross abnormalities are seen in the cochlear duct or its accessory structures

increased or absent threshold for auditory brainstem response ( J:167669 )

• increased threshold or absent at the highest frequency test (41.2 Hz) at 21 months of age

reduced linear vestibular evoked potential ( J:167669 )

• increase in VsEP thresholds at 13 and 21 months of age

Allelic Composition	Coch^tm1.1Stw/Coch^tm1.1Stw
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coch^tm1.1Stw mutation (2 available); any Coch mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:105566 , J:108251 )

• surprisingly, homozygotes are viable and overtly normal and females display no defects in implantation or reproduction relative to wild-type littermates (J:105566)

• at ~5 months, homozygotes do not display any apparent inner ear histopathology or any significant hearing loss relative to wild-type mice (J:108251)

Allelic Composition	Coch^tm1.1Stw/Coch^tm1.1Stw
Genetic Background	involves: 129S1/Sv * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coch^tm1.1Stw mutation (2 available); any Coch mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:116965 )

N	• at P19, 3- and 5- months of age, homozygotes exhibit no significant differences in auditory brainstem responses to click and pure-tone stimuli (8, 16, 32 kHz) relative to wild-type mice

Allelic Composition	Coch^tm1.1Stw/Coch⁺
Genetic Background	CBACa.129S1-Coch^tm1.1Stw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coch^tm1.1Stw mutation (2 available); any Coch mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:167669 )

N	• unlike in homozygous mutant mice, no hearing deficit is detected at any age

reduced linear vestibular evoked potential ( J:167669 )

• increase in VsEP thresholds at 21 months of age

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