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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm2Emo
targeted mutation 2, Eugene M Oltz
MGI:3624531
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm2Emo/Ightm2Emo involves: 129S1/Sv * C57BL/6 * FVB/N MGI:3630305


Genotype
MGI:3630305
hm1
Allelic
Composition		 Ightm2Emo/Ightm2Emo
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Emo mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:108098 )
• homozygotes show a 10-fold decrease in proportion of B220+IgM+ cells demonstrating a block of B cell development
absent pre-B cells ( J:108098 )
• bone marrow of mice is severely deficient in pre-B cells compared to wild-type

hematopoietic system
abnormal B cell differentiation ( J:108098 )
• homozygotes show a 10-fold decrease in proportion of B220+IgM+ cells demonstrating a block of B cell development
absent pre-B cells ( J:108098 )
• bone marrow of mice is severely deficient in pre-B cells compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory