All Phenotypes Pttg1<tm1.2Kna> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pttg1^tm1.2Kna
targeted mutation 1.2, Kim Nasmyth
MGI:3624203

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pttg1^tm1.2Kna/Pttg1^tm1.2Kna	involves: 129P2/OlaHsd * C57BL/6	MGI:3625274
cx2	Espl1^tm1.2Kna/Espl1⁺ Pttg1^tm1.2Kna/Pttg1^tm1.2Kna	involves: 129P2/OlaHsd * C57BL/6	MGI:3625275

Allelic Composition	Pttg1^tm1.2Kna/Pttg1^tm1.2Kna
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pttg1^tm1.2Kna mutation (0 available); any Pttg1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced fertility ( J:107916 )

Allelic Composition	Espl1^tm1.2Kna/Espl1⁺ Pttg1^tm1.2Kna/Pttg1^tm1.2Kna
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Pttg1^tm1.2Kna mutation (0 available); any Pttg1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107916 )

• die at E11.5

cellular

abnormal cell nucleus morphology ( J:107916 )

• at E9.5 larger, lobed nuclei are seen in several organs, including the somites, heart, and brain

• after 10 days in culture MEFs have large lobed nuclei

abnormal mitosis ( J:107916 )

• 16 of 24 mitotic MEF cells had multipolar spindles and 8 were undergoing anaphase with lagging chromosomes

abnormal mitotic spindle morphology ( J:107916 )

• 16 of 24 mitotic MEF cells had multipolar spindles

abnormal cell death ( J:107916 )

• extensive cell death is seen at E9.5

embryo

decreased embryo size ( J:107916 )

• at E10.5

abnormal neural tube morphology ( J:107916 )

• at E10.5

abnormal somite development ( J:107916 )

• irregular somites are seen at E10.5

nervous system

abnormal neural tube morphology ( J:107916 )

• at E10.5

growth/size/body

decreased embryo size ( J:107916 )

• at E10.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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