Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-PGDS)1Groy
• Allele Name: transgene insertion 1, Derek W Gilroy
• Allele ID: MGI:3624138
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-PGDS)1Groy/0	involves: FVB/N	MGI:3624258

Genotype
MGI:3624258

tg1

• Allelic Composition: Tg(CAG-PGDS)1Groy/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymph node morphology ( J:107651 )

• in response to BSA or concanavalin A, lymph node cellular proliferation is significantly decreased in cultures from transgenic mice at all time points compared to wild-type controls

abnormal cytokine secretion ( J:107651 )

• in response to BSA or concanavalin A, Il-2 levels in lymph node cultures from transgenic mice are much lower than in cultures from control mice at 24 hours

decreased inflammatory response ( J:107651 )

• upon injection of BSA into sensitized transgenic mice, paw swelling is undetectable compared to controls