Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1tm1Hko mutation
(0 available);
any
Hipk1 mutation
(61 available)
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cellular
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• embryonic fibroblasts from null mice are slightly resistant to UV radiation compared to wild-type
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nervous system
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• neural tube defects occur more frequently in female compound mutants
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embryo
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• neural tube defects occur more frequently in female compound mutants
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1tm1Hko mutation
(0 available);
any
Hipk1 mutation
(61 available)
Hipk2tm1Hko mutation
(0 available);
any
Hipk2 mutation
(53 available)
Trp53tm2Mok mutation
(2 available);
any
Trp53 mutation
(232 available)
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nervous system
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• four triple mutants were found to be exencephalic, whereas none were found to be wild-type for Trp53
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1tm1Hko mutation
(0 available);
any
Hipk1 mutation
(61 available)
Hipk2tm1Hko mutation
(0 available);
any
Hipk2 mutation
(53 available)
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mortality/aging
growth/size/body
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• at E9.5, 14 of 17 live double homozygotes are smaller and developmentally delayed compared to Hipk1tm1Kho homozygous or Hipk1tm1Kho/Hipk1tm1Kho Hipk2+/+ embryos
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cellular
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• significantly more apoptotic cells are observed in the condensing trigeminal and facioacoustic neural crest cells, as well as in the sclerotomal compartment, compared to Hipk1-null, Hipk2-wild-type mutants
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• at E9.5, the frequency of mitotic cells in the cranial and caudal regions of the neural tube of double homozygotes is reduced to 45% and 29% compared to Hipk1-null, Hipk2 wild-type homozygotes
• proliferation of the cephalic mesoderm is reduced to 43% of that in Hipk1-null, Hipk2-wild-type double mutants
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nervous system
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• neural tube defects occur more frequently in female compound mutants
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• half of the homozygous embryos surviving to beyond E9.5 exhibit exencephaly
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vision/eye
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• in mutants lens vesicle formation fails with disorientation of the optic cups and fusion of the dorsal root ganglia
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embryo
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• at E9.5, 14 of 17 live double homozygotes are smaller and developmentally delayed compared to Hipk1tm1Kho homozygous or Hipk1tm1Kho/Hipk1tm1Kho Hipk2+/+ embryos
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• neural tube defects occur more frequently in female compound mutants
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1tm1Hko mutation
(0 available);
any
Hipk1 mutation
(61 available)
Hipk2tm1Hko mutation
(0 available);
any
Hipk2 mutation
(53 available)
|
|
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mortality/aging
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• about half of the mutants are lost during gestation, compared to the predicted number
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cellular
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• embryonic fibroblasts from mutant mice are more resistant to UV radiation compared to single Hipk1 or Hipk2-null mice
• decreased numbers of apoptotic cells induced by UV irradiation are observed in MEFs compared to wild-type
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nervous system
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• neural tube defects occur more frequently in female compound mutants
|
embryo
|
• neural tube defects occur more frequently in female compound mutants
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hipk1tm1Hko mutation
(0 available);
any
Hipk1 mutation
(61 available)
Hipk2tm1Hko mutation
(0 available);
any
Hipk2 mutation
(53 available)
|
|
|
nervous system
|
• neural tube defects occur more frequently in female compound mutants
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• a small number of these mutants exhibit exencephaly
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embryo
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• neural tube defects occur more frequently in female compound mutants
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