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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Espl1tm1.2Tno
targeted mutation 1.2 Tetsuo Noda
MGI:3624003
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Espl1tm1.2Tno/Espl1tm1.2Tno involves: 129S4/SvJae * C57BL/6J MGI:3714321
cn2
Espl1tm1.1Tno/Espl1tm1.2Tno involves: 129S4/SvJae * C57BL/6J MGI:3714319
cx3
Espl1tm1.2Tno/Espl1+
Pttg1tm1.1Tno/Pttg1tm1.1Tno
involves: 129S4/SvJae * C57BL/6J MGI:3714317


Genotype
MGI:3714321
hm1
Allelic
Composition
Espl1tm1.2Tno/Espl1tm1.2Tno
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.2Tno mutation (0 available); any Espl1 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although homozygous blastocysts are present at E3.5, no homozygous embryos are recovered at E8.5

embryo
• trophoblasts do not spread in a E3.5 embryo after day 3 in culture
• blastocyst are smaller than normal
• E3.5 embryos after day 1 in culture have 10% of the cells in a normal blastocyst and have enlarged nuclei by 2 times the normal diameter
• E3.5 embryos after day 3 in culture fail to either expand the inner cell mass and trophoblasts do not spread

cellular
• E3.5 embryos after day 1 in culture have enlarged nuclei by 2 times the normal diameter
• trophoblasts do not spread in a E3.5 embryo after day 3 in culture




Genotype
MGI:3714319
cn2
Allelic
Composition
Espl1tm1.1Tno/Espl1tm1.2Tno
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Tno mutation (0 available); any Espl1 mutation (95 available)
Espl1tm1.2Tno mutation (0 available); any Espl1 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• following treatment with Cre-adenovirus, mouse embryonic fibroblasts (MEFs) have enlarged nuclei
• following treatment with Cre-adenovirus, mouse embryonic fibroblasts (MEFs) exhibit growth retardation
• DNA replication continues to occur
• however, infection with Cre-adenovirus can reduce some growth in the absence of floxed alleles




Genotype
MGI:3714317
cx3
Allelic
Composition
Espl1tm1.2Tno/Espl1+
Pttg1tm1.1Tno/Pttg1tm1.1Tno
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.2Tno mutation (0 available); any Espl1 mutation (95 available)
Pttg1tm1.1Tno mutation (0 available); any Pttg1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups die prior to E12.5

growth/size/body

embryo





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory