About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm2Wahl
targeted mutation 2, Geoffrey M Wahl
MGI:3623943
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm2Wahl/Trp53tm2Wahl involves: 129S4/SvJae * C57BL/6 MGI:3714349
cx2
 		Mdm2tm1Glo/Mdm2+
Trp53tm2Wahl/Trp53tm2Wahl 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:5285192
cx3
 		Cdkn1atm1Hpw/Cdkn1a+
Trp53tm2Wahl/Trp53tm2Wahl 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5285193


Genotype
MGI:3714349
hm1
Allelic
Composition		 Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:174375 )
N
• mice exhibit normal lifespan and aging
increased mortality induced by ionizing radiation ( J:174375 )
• all mice die within 4 weeks of irradiation unlike similarly treated wild-type mice

hematopoietic system
abnormal definitive hematopoiesis ( J:174375 )
• irradiated mice exhibit intra- and extramedullary hematopoiesis that does not compensate for pancytopenia unlike in wild-type mice
decreased common myeloid progenitor cell number ( J:174375 )
• irradiated mice exhibit a more severe decrease in granulocytic/macrophage (CFU-GM) compared with wild-type mice
decreased bone marrow cell number ( J:174375 )
• after irradiation, mice exhibit atrophy of hematopoietic cells in the bone marrow compared with similarly treated wild-type mice
decreased erythroid progenitor cell number ( J:174375 )
• irradiated mice exhibit a more severe decrease in erythroid (BFU-E) compared with wild-type mice
abnormal megakaryocyte progenitor cell morphology ( J:174375 )
• irradiated mice exhibit a more severe decrease in megakaryocytic (CFU-MK) compared with wild-type mice
decreased erythrocyte cell number ( J:174375 )
• slightly prior to irradiation
• after irradiation
decreased hematocrit ( J:174375 )
• in irradiated mice
thrombocytopenia ( J:174375 )
• slightly prior to irradiation
• after irradiation
decreased leukocyte cell number ( J:174375 )
• slightly prior to irradiation
• after irradiation
decreased spleen red pulp amount ( J:174375 )
• after irradiation
abnormal hematopoietic stem cell physiology ( J:174375 )
• hematopoietic stem cells compete poorly with wild-type cells in transplantation assays and are more sensitive to irradiation compared with wild-type cells

cardiovascular system
enlarged heart ( J:174375 )
• in irradiated mice
increased heart weight ( J:174375 )
• in irradiated mice

integument
pallor ( J:174375 )
• in irradiated mice

immune system
decreased leukocyte cell number ( J:174375 )
• slightly prior to irradiation
• after irradiation
decreased spleen red pulp amount ( J:174375 )
• after irradiation

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:174375 )
• all mice die within 4 weeks of irradiation unlike similarly treated wild-type mice

growth/size/body
enlarged heart ( J:174375 )
• in irradiated mice
increased heart weight ( J:174375 )
• in irradiated mice




Genotype
MGI:5285192
cx2
Allelic
Composition		 Mdm2tm1Glo/Mdm2+
Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by ionizing radiation ( J:174375 )
• compared with Mdm2tm1Glo heterozygotes

hematopoietic system
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes
decreased erythrocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
thrombocytopenia ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
decreased leukocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
spleen atrophy ( J:174375 )
• severe in irradiated-mice

skeleton
abnormal bone marrow morphology ( J:174375 )
• severe atrophic in irradiated-mice

immune system
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes
decreased leukocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
spleen atrophy ( J:174375 )
• severe in irradiated-mice

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:174375 )
• compared with Mdm2tm1Glo heterozygotes

endocrine/exocrine glands
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes




Genotype
MGI:5285193
cx3
Allelic
Composition		 Cdkn1atm1Hpw/Cdkn1a+
Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Hpw mutation (1 available); any Cdkn1a mutation (60 available)
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased mortality induced by ionizing radiation ( J:174375 )
• compared with irradiated Trp53tm2Wahl homozygotes

homeostasis/metabolism
decreased mortality induced by ionizing radiation ( J:174375 )
• compared with irradiated Trp53tm2Wahl homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory