Phenotypes associated with this allele

• Allele Symbol: Cdkn1b^tm3Mlf
• Allele Name: targeted mutation 3, Matthew L Fero
• Allele ID: MGI:3623441
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn1b^tm3Mlf/Cdkn1b^tm3Mlf	involves: 129S4/SvJaeSor	MGI:3624682
cn2	Cdkn1b^tm3Mlf/Cdkn1b^tm3Mlf Tg(Pomc1-cre)1Mlf/0	involves: 129S4/SvJaeSor	MGI:3624683

Genotype
MGI:3624682

hm1

• Allelic Composition: Cdkn1b^tm3Mlf/Cdkn1b^tm3Mlf
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107588 )

• mice have significantly shortened life spans compared to wild-type or POMC-transgene expressing mutants

neoplasm

increased pituitary gland tumor incidence ( J:107588 )

• mice develop spontaneous pituitary tumors

growth/size/body

increased body size ( J:107588 )

• mutants are significantly larger than wild-type

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:107588 )

• mice develop spontaneous pituitary tumors

nervous system

increased pituitary gland tumor incidence ( J:107588 )

• mice develop spontaneous pituitary tumors

Genotype
MGI:3624683

cn2

• Allelic Composition: Cdkn1b^tm3Mlf/Cdkn1b^tm3Mlf; Tg(Pomc1-cre)1Mlf/0
• Genetic Background: involves: 129S4/SvJaeSor

mortality/aging

premature death ( J:107588 )

• mice have shortened life spans compared to wild-type but increased survival times compared to Cdkn1b-deficient (nontransgenic) animals

neoplasm

decreased tumor incidence ( J:107588 )

• transgenic mice are mostly resistant to tumor formation, but some develop smaller pituitary tumors at 1 year of age; before 1 year of age, 32% of mutants die from nonmalignant skin ulcers, but only two of these were found to have large pituitary tumors