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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdkn1btm2Mlf
targeted mutation 2, Matthew L Fero
MGI:3623439
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cdkn1btm2Mlf/Cdkn1btm2Mlf
Tg(Pomc1-cre)1Mlf/0 		involves: 129S4/SvJaeSor MGI:3624681


Genotype
MGI:3624681
cn1
Allelic
Composition		 Cdkn1btm2Mlf/Cdkn1btm2Mlf
Tg(Pomc1-cre)1Mlf/0
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm2Mlf mutation (1 available); any Cdkn1b mutation (25 available)
Tg(Pomc1-cre)1Mlf mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:107588 )
• mice have shortened life spans compared to wild-type but increased survival times compared to Cdkn1b-deficient (nontransgenic) animals

neoplasm
increased pituitary gland tumor incidence ( J:107588 )
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice

endocrine/exocrine glands
increased pituitary gland tumor incidence ( J:107588 )
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice

nervous system
increased pituitary gland tumor incidence ( J:107588 )
• transgenic mice develop pituitary tumors at an increased incidence over wild-type or nontransgenic mutant mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory