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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hcls1tm2Wtn
targeted mutation 2, Takeshi Watanabe
MGI:3623118
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hcls1tm2Wtn/Hcls1tm2Wtn involves: 129P2/OlaHsd * C57BL/6 MGI:3625315


Genotype
MGI:3625315
hm1
Allelic
Composition		 Hcls1tm2Wtn/Hcls1tm2Wtn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcls1tm2Wtn mutation (0 available); any Hcls1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
decreased B cell number ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
abnormal B cell physiology ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown

immune system
decreased T cell proliferation ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
decreased B cell number ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
abnormal B cell physiology ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown
abnormal humoral immune response ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown

cellular
decreased T cell proliferation ( J:28146 )
• phenotype is reported to be essentially identical to Hlcstm1Wtn homozygosity; no data is shown




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/30/2025
MGI 6.24 		The Jackson Laboratory