Phenotypes associated with this allele

• Allele Symbol: P2ry1^tm1Bhk
• Allele Name: targeted mutation 1, Beverly H Koller
• Allele ID: MGI:3623115
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P2ry1^tm1Bhk/P2ry1^tm1Bhk	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3623279

Genotype
MGI:3623279

hm1

• Allelic Composition: P2ry1^tm1Bhk/P2ry1^tm1Bhk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased platelet aggregation ( J:57960 )

• platelets from mutant mice do not aggregate in response to ADP, low doses of collagen or a thromboxane A2 receptor agonist where wild-type platelets aggregate to these stimuli

• wild-type platelets transmit less light upon exposure to EDTA, whereas platelets from mutants do not, indicating that platelets do not undergo any shape change

abnormal thrombolysis ( J:57960 )

• mutants injected with collagen and ADP to induce thrombi all survived for the 1 hour observation period, while 90% of wild-type mice died within 5 minutes of injection

increased bleeding time ( J:57960 )

• after tail tip amputation, mutant mice continue to bleed for 24 minutes, while wild-type control the bleeding after 10 minutes

hematopoietic system

decreased platelet aggregation ( J:57960 )

• platelets from mutant mice do not aggregate in response to ADP, low doses of collagen or a thromboxane A2 receptor agonist where wild-type platelets aggregate to these stimuli

• wild-type platelets transmit less light upon exposure to EDTA, whereas platelets from mutants do not, indicating that platelets do not undergo any shape change