Phenotypes associated with this allele

• Allele Symbol: Afdn^tm1Ytk
• Allele Name: targeted mutation 1, Yoshimi Takai
• Allele ID: MGI:3623108
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Afdn^tm1Ytk/Afdn^tm1Ytk	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:3639321

Genotype
MGI:3639321

hm1

• Allelic Composition: Afdn^tm1Ytk/Afdn^tm1Ytk
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:57589 )

• no homozygotes detected from E10.5

growth/size/body

decreased embryo size ( J:57589 )

• embryos are flat and short

embryo

abnormal ectoderm development ( J:57589 )

• ectoderm is disorganized with cell-cell adherens junctions and tight junctions improperly organized in the ectoderm

• ectodermal cells appear flat or cuboid and their polarized epithelial structures appear to be entirely impaired

• exhibit invagination of the ectoderm to the amniotic side

• at the region of the neural fold/groove, the ectoderm becomes multilayered and appears as a cell mass

abnormal mesoderm development ( J:57589 )

• delamination/migration of the mesoderm is impaired

decreased embryo size ( J:57589 )

• embryos are flat and short

abnormal neural tube morphology ( J:57589 )

• neural tube does not form

abnormal somite development ( J:57589 )

• although exhibit somite-like blocks, no epithelial structure of somites is established

absent allantois ( J:57589 )

• formation of the allantois is not observed

abnormal amniotic cavity morphology ( J:57589 )

• the amniotic cavity does not develop normally and is compressed to an inverted U-shape

abnormal extraembryonic coelom morphology ( J:57589 )

• the exocoelomic cavity does not develop normally

cardiovascular system

absent heart ( J:57589 )

• heart does not develop

nervous system

abnormal neural tube morphology ( J:57589 )

• neural tube does not form