Phenotypes associated with this allele

• Allele Symbol: Tcea1^tm1Skmz
• Allele Name: targeted mutation 1, Kazuhisa Sekimizu
• Allele ID: MGI:3622786
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcea1^tm1Skmz/Tcea1^tm1Skmz	involves: 129P2/OlaHsd * C57BL/6JJcl	MGI:3625036

Genotype
MGI:3625036

hm1

• Allelic Composition: Tcea1^tm1Skmz/Tcea1^tm1Skmz
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:107421 )

• occurs between E13.5 and E16.5 with severe anemia

hematopoietic system

abnormal erythropoiesis ( J:107421 )

• definitive erythropoiesis is severely impaired

• at E13.5 clusters of apoptotic cells surrounding a single non-apoptotic cell are seen in the fetal liver suggesting a massive increase in erythroblast apoptosis

• transplanted fetal liver cells fail to contribute to the peripheral blood cell population in irradiated recipients

anemia ( J:107421 )

• severe

abnormal hematopoietic stem cell morphology ( J:107421 )

• expansion of hematopoietic stem cells is impaired and the number of late erythroblasts is reduced

liver/biliary system

liver hypoplasia ( J:107421 )

• at E12.5 and E13.5

pale liver ( J:107421 )

• at E13.5

embryo

decreased embryo size ( J:107421 )

• at E13.5

limbs/digits/tail

curly tail ( J:107421 )

• at E12.5

cardiovascular system

pericardial edema ( J:107421 )

• at E13.5

growth/size/body

decreased embryo size ( J:107421 )

• at E13.5

homeostasis/metabolism

pericardial edema ( J:107421 )

• at E13.5