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Allele Symbol Allele Name Allele ID |
Sp4tm2Krc targeted mutation 2, Kenneth R Chien MGI:3621970 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40, with it being dispersed throughout the cell instead of localized along the cell boundaries as in wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40 in the peripheral conduction system compared to wild-type and ventricular-specific null animals
• mice have abnormalities in the innervation to the AVN region
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• atrial paced 2:1 atrioventricular block rates are higher in nulls compared to wild-type
• atrial effective refractory periods are lengthened in null animals
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• in mutants, there is a marked disorganization of a marker for cardiac Purkinje cells Cx40 in the peripheral conduction system compared to wild-type and ventricular-specific null animals
• mice have abnormalities in the innervation to the AVN region
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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