Analysis Tools
growth/size/body
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• at 7 weeks of age, male and female mutants on a regular chow diet have gained less weight than wild-type, the effect being more apparent in male mutants which have a significantly lower body weight and fat mass compared to controls
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weight loss
(
J:106819
)
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• at 15 weeks of age, nulls lose more weight in response to 24 hours of food deprivation; mutants lost 9.9% of body weight compared to 7.4% of body weight for controls
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• when fed a high fat diet, mutants gain less weight; in male this is more pronounced at 7 weeks, while in females it reaches significance at 14 weeks (12% lower than wild-type; males weigh 15% less than wild-type at 14 weeks)
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homeostasis/metabolism
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• because of the reduction in fat mass, both male and female mutants have lower insulin levels compared to wild-type
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• male mutants have lower circulating leptin levels compared to wild-type at 15 weeks of age
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• male knockouts have reduced fuel efficiency (body weight gain per kilocalorie food intake); at 11 and 14 weeks of age, total energy expenditure is 28% higher in mutants compared with wild-type over a 24 hour period; during a 24 hour fast, male mutants expend 11% more energy than wild-type
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• when fed a high fat diet, mutants gain less weight; in male this is more pronounced at 7 weeks, while in females it reaches significance at 14 weeks (12% lower than wild-type; males weigh 15% less than wild-type at 14 weeks)
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behavior/neurological
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• female mutants consume 15% more food than controls; males consume 20% more than controls
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adipose tissue
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• in mutants, fat mass is reduced by 30% in females and 50% in males compared to wild-type at 15 weeks of age
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