Phenotypes associated with this allele

• Allele Symbol: Postn^tm1Kudo
• Allele Name: targeted mutation 1, Akira Kudo
• Allele ID: MGI:3621456
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Postn^tm1Kudo/Postn^tm1Kudo	B6.Cg-Postn^tm1Kudo	MGI:3819683
hm2	Postn^tm1Kudo/Postn^tm1Kudo	Not Specified	MGI:3622422

Genotype
MGI:3819683

hm1

• Allelic Composition: Postn^tm1Kudo/Postn^tm1Kudo
• Genetic Background: B6.Cg-Postn^tm1Kudo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:131434 )

• survival rate after acute myocardial infarction is lower (17.58% vs. 53.76% at day 10) than in wild-type

• incidence of mortality caused by cardiac rupture is higher (68.1% vs. 31.3%) than in wild-type after acute myocardial infarction

cardiovascular system

cardiovascular system phenotype ( J:131434 )

N • under normal conditions, no cardiomyoctye abnormalities are seen in the myocardium, and valve function, pulsation and blood pressure appear normal

abnormal response to cardiac infarction ( J:131434 )

• after acute myocardial infarction, cardiac healing is impaired, resulting in cardiac rupture as a consequence of reduced myocardial stiffness caused by a reduction of alpha smooth muscle actin-positive cells and impaired collagen fibril formation

homeostasis/metabolism

abnormal response to cardiac infarction ( J:131434 )

• after acute myocardial infarction, cardiac healing is impaired, resulting in cardiac rupture as a consequence of reduced myocardial stiffness caused by a reduction of alpha smooth muscle actin-positive cells and impaired collagen fibril formation

neoplasm

increased tumor growth/size ( J:131295 )

• growth of tumors allografted into mutants is significantly accelerated compared to tumors grafted into wild type mice

• size of transplanted tumors is larger than in wild type

• increased tumor growth results from impaired ECM formation by stromal cells and not due to an increase in angiogenesis

Genotype
MGI:3622422

hm2

• Allelic Composition: Postn^tm1Kudo/Postn^tm1Kudo
• Genetic Background: Not Specified

craniofacial

abnormal periodontal ligament morphology ( J:106783 )

• at 6 weeks of age, the shear zone (area between the tooth- and alveolus-related regions of the periodontal ligament) is obscure and by 12 weeks the shear zone is undetectable and the periodontal ligament is wider

abnormal tooth eruption ( J:106783 )

• incisor eruption is disrupted

abnormal tooth hard tissue morphology ( J:106783 )

abnormal dentin morphology ( J:106783 )

• at 6 weeks of age the dentin layer is thicker and gently waved

• by 12 weeks of age the dentin layer is compressed and undulated

abnormal enamel morphology ( J:106783 )

• incisors are a chalky, white color indicating that the enamel layers are disorganized

• at 6 weeks of age the enamel layer is thicker and gently waved

• by 12 weeks of age the enamel layer is compressed and undulated

abnormal ameloblast morphology ( J:106783 )

• at 6 weeks of age the ameloblastic layers show focal disorganization

• at 12 weeks of age the ameloblast layer is loosened, contains some non-polarized cells, gaps are seen between the polarized cells, and the morphology and alignment of cells is severely disrupted

skeleton

abnormal periodontal ligament morphology ( J:106783 )

• at 6 weeks of age, the shear zone (area between the tooth- and alveolus-related regions of the periodontal ligament) is obscure and by 12 weeks the shear zone is undetectable and the periodontal ligament is wider

abnormal tooth eruption ( J:106783 )

• incisor eruption is disrupted

abnormal tooth hard tissue morphology ( J:106783 )

abnormal dentin morphology ( J:106783 )

• at 6 weeks of age the dentin layer is thicker and gently waved

• by 12 weeks of age the dentin layer is compressed and undulated

abnormal enamel morphology ( J:106783 )

• incisors are a chalky, white color indicating that the enamel layers are disorganized

• at 6 weeks of age the enamel layer is thicker and gently waved

• by 12 weeks of age the enamel layer is compressed and undulated

abnormal ameloblast morphology ( J:106783 )

• at 6 weeks of age the ameloblastic layers show focal disorganization

• at 12 weeks of age the ameloblast layer is loosened, contains some non-polarized cells, gaps are seen between the polarized cells, and the morphology and alignment of cells is severely disrupted

growth/size/body

abnormal periodontal ligament morphology ( J:106783 )

• at 6 weeks of age, the shear zone (area between the tooth- and alveolus-related regions of the periodontal ligament) is obscure and by 12 weeks the shear zone is undetectable and the periodontal ligament is wider

abnormal tooth eruption ( J:106783 )

• incisor eruption is disrupted

abnormal tooth hard tissue morphology ( J:106783 )

abnormal dentin morphology ( J:106783 )

• at 6 weeks of age the dentin layer is thicker and gently waved

• by 12 weeks of age the dentin layer is compressed and undulated

abnormal enamel morphology ( J:106783 )

• incisors are a chalky, white color indicating that the enamel layers are disorganized

• at 6 weeks of age the enamel layer is thicker and gently waved

• by 12 weeks of age the enamel layer is compressed and undulated

abnormal ameloblast morphology ( J:106783 )

• at 6 weeks of age the ameloblastic layers show focal disorganization

• at 12 weeks of age the ameloblast layer is loosened, contains some non-polarized cells, gaps are seen between the polarized cells, and the morphology and alignment of cells is severely disrupted