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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MMTV-CCND1)1Esmp
transgene insertion 1, Emmett V Schmidt
MGI:3621189
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(MMTV-CCND1)1Esmp/0
Tg(MMTV-Cdc37)1Stp/0 		involves: C57BL/6 * DBA/2 * FVB/N MGI:3839910
cx2
 		Chuktm2Mka/Chuktm2Mka
Tg(MMTV-CCND1)1Esmp/? 		Not Specified MGI:3847938
tg3
 		Tg(MMTV-CCND1)1Esmp/0 Not Specified MGI:3839901


Genotype
MGI:3839910
cx1
Allelic
Composition		 Tg(MMTV-CCND1)1Esmp/0
Tg(MMTV-Cdc37)1Stp/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-CCND1)1Esmp mutation (0 available)
Tg(MMTV-Cdc37)1Stp mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:62465 )
• in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice
• female mice exhibit metastasis to the lungs
increased mammary adenocarcinoma incidence ( J:62465 )
• female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated

integument
increased mammary gland tumor incidence ( J:62465 )
• in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice
• female mice exhibit metastasis to the lungs
increased mammary adenocarcinoma incidence ( J:62465 )
• female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:62465 )
• in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice
• female mice exhibit metastasis to the lungs
increased mammary adenocarcinoma incidence ( J:62465 )
• female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated




Genotype
MGI:3847938
cx2
Allelic
Composition		 Chuktm2Mka/Chuktm2Mka
Tg(MMTV-CCND1)1Esmp/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm2Mka mutation (0 available); any Chuk mutation (48 available)
Tg(MMTV-CCND1)1Esmp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:90978 )
N
• the lactation defect observed in single Chuk mutants is completely suppressed by transgene expression and mice exhibit normal lobuloalveolar development




Genotype
MGI:3839901
tg3
Allelic
Composition		 Tg(MMTV-CCND1)1Esmp/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:70571 )
• 4 of 9 mice develop multiple independent tumors
increased mammary gland tumor incidence ( J:70571 )
• in 5 of 9 mice with mean onset at 551 days
increased mammary adenocarcinoma incidence ( J:70571 )
• with papillary and cribriform elements
increased testis tumor incidence ( J:70571 )
• some mice develop testicular sarcomas with metastasis to the liver and spindle cell sarcoma of the uterine wall
increased sarcoma incidence ( J:70571 )
• some mice develop metastatic spindle cell sarcoma of the uterine wall

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:70571 )
• in 5 of 9 mice with mean onset at 551 days
increased mammary adenocarcinoma incidence ( J:70571 )
• with papillary and cribriform elements
increased testis tumor incidence ( J:70571 )
• some mice develop testicular sarcomas with metastasis to the liver and spindle cell sarcoma of the uterine wall

integument
increased mammary gland tumor incidence ( J:70571 )
• in 5 of 9 mice with mean onset at 551 days
increased mammary adenocarcinoma incidence ( J:70571 )
• with papillary and cribriform elements

reproductive system
increased testis tumor incidence ( J:70571 )
• some mice develop testicular sarcomas with metastasis to the liver and spindle cell sarcoma of the uterine wall




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory