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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		DtnbGt(OST109050)Lex
gene trap OST109050, Lexicon Genetics
MGI:3621006
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3621489
cx2
 		Dtnatm1Jrs/Dtnatm1Jrs
DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex 		involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:3621490


Genotype
MGI:3621489
hm1
Allelic
Composition		 DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
DtnbGt(OST109050)Lex mutation (0 available); any Dtnb mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:106640 )
• mice are viable, fertile and outwardly normal; no significant synaptic or behavioral abnormalities are observed




Genotype
MGI:3621490
cx2
Allelic
Composition		 Dtnatm1Jrs/Dtnatm1Jrs
DtnbGt(OST109050)Lex/DtnbGt(OST109050)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dtnatm1Jrs mutation (1 available); any Dtna mutation (45 available)
DtnbGt(OST109050)Lex mutation (0 available); any Dtnb mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:106640 )
• mutants have significantly decreased performance in ability to balance on a small platform, to hang from an inverted screen, or to balance on a rotating rod at constant or accelerating speeds
decreased grip strength ( J:106640 )
• double mutants have significantly poorer performance in a forelimb grip strength test

nervous system
abnormal CNS synapse formation ( J:106640 )
• in double knockouts, inhibitory synapse formation in the cerebellum is defective




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory