Phenotypes associated with this allele

• Allele Symbol: Dtnb^{Gt(OST109050)Lex}
• Allele Name: gene trap OST109050, Lexicon Genetics
• Allele ID: MGI:3621006
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dtnb^Gt(OST109050)Lex/Dtnb^Gt(OST109050)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3621489
cx2	Dtna^tm1Jrs/Dtna^tm1Jrs Dtnb^Gt(OST109050)Lex/Dtnb^Gt(OST109050)Lex	involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:3621490

Genotype
MGI:3621489

hm1

• Allelic Composition: Dtnb^{Gt(OST109050)Lex}/Dtnb^{Gt(OST109050)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:106640 )

• mice are viable, fertile and outwardly normal; no significant synaptic or behavioral abnormalities are observed

Genotype
MGI:3621490

cx2

• Allelic Composition: Dtna^tm1Jrs/Dtna^tm1Jrs; Dtnb^{Gt(OST109050)Lex}/Dtnb^{Gt(OST109050)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * 129X1/SvJ * C57BL/6

behavior/neurological

impaired coordination ( J:106640 )

• mutants have significantly decreased performance in ability to balance on a small platform, to hang from an inverted screen, or to balance on a rotating rod at constant or accelerating speeds

decreased grip strength ( J:106640 )

• double mutants have significantly poorer performance in a forelimb grip strength test

nervous system

abnormal CNS synapse formation ( J:106640 )

• in double knockouts, inhibitory synapse formation in the cerebellum is defective