All Phenotypes Lmna<tm2Lgf> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmna^tm2Lgf
targeted mutation 2, Loren G Fong
MGI:3620627

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmna^tm2Lgf/Lmna^tm2Lgf	involves: 129S4/SvJae * C57BL/6	MGI:3620905
ht2	Lmna^tm2Lgf/Lmna^tm7Lgf	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4840106
ht3	Lmna^tm1Stw/Lmna^tm2Lgf	involves: 129S1/Sv * 129S4/SvJae * C57BL/6	MGI:3620906
cx4	Lmna^tm2Lgf/Lmna⁺ Zmpste24^tm1Sgy/Zmpste24^tm1Sgy	involves: 129S4/SvJae * C57BL/6	MGI:3620908

Allelic Composition	Lmna^tm2Lgf/Lmna^tm2Lgf
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm2Lgf mutation (0 available); any Lmna mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:106473 )

• viable and fertile with normal growth, muscle strength, and bone morphology

Allelic Composition	Lmna^tm2Lgf/Lmna^tm7Lgf
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm2Lgf mutation (0 available); any Lmna mutation (82 available)
Lmna^tm7Lgf mutation (0 available); any Lmna mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell nucleus morphology ( J:165928 )

• misshapen

Allelic Composition	Lmna^tm1Stw/Lmna^tm2Lgf
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm1Stw mutation (3 available); any Lmna mutation (82 available)
Lmna^tm2Lgf mutation (0 available); any Lmna mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:106473 )

• viable and fertile with normal growth and muscle strength

Allelic Composition	Lmna^tm2Lgf/Lmna⁺ Zmpste24^tm1Sgy/Zmpste24^tm1Sgy
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm2Lgf mutation (0 available); any Lmna mutation (82 available)
Zmpste24^tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:106473 )

N	• no bone fractures or other skeletal abnormalities are seen

cellular

cellular phenotype ( J:106473 )

N	• far fewer misshapen nuclei in MEFs

growth/size/body

growth/size/body region phenotype ( J:106473 )

N	• normal growth

muscle

muscle phenotype ( J:106473 )

N	• muscle strength is similar to wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23