Phenotypes associated with this allele

• Allele Symbol: Plod3^tm2Rmyl
• Allele Name: targeted mutation 2, Raili Myllyla
• Allele ID: MGI:3620601
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plod3^tm2Rmyl/Plod3^tm2Rmyl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3620941

Genotype
MGI:3620941

hm1

• Allelic Composition: Plod3^tm2Rmyl/Plod3^tm2Rmyl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:106510 )

• begin to die around E9.5 and loss of embryos continues through E14.5 with 1 mouse surviving to birth but dying shortly after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:106510 )

• begin to die around E9.5 and loss of embryos continues through E14.5 with 1 mouse surviving to birth but dying shortly after birth

embryo

embryonic growth retardation ( J:106510 )

• severely affected embryos show growth retardation at E8.5 and die before E10.5

• almost all of the rest of the embryos show mild growth retardation and die before E14.5

abnormal neural tube morphology ( J:106510 )

• the basement membrane is present but discontinuous and fragmented

abnormal Reichert's membrane morphology ( J:106510 )

• abnormal type IV collagen staining

nervous system

intracranial hemorrhage ( J:106510 )

• seen at E12.5-E13.5

abnormal neural tube morphology ( J:106510 )

• the basement membrane is present but discontinuous and fragmented

cardiovascular system

abnormal vascular endothelial cell morphology ( J:106510 )

• the basement membranes are absent or sometimes replaced with amorphous material

• the endoplasmic reticulum is dilated, apoptosis is increased, and ruptures of the endothelial cell layer are seen

intracranial hemorrhage ( J:106510 )

• seen at E12.5-E13.5

increased vasodilation ( J:106510 )

• severely affected embryos have dilated blood vessels especially around the sinus venosus

growth/size/body

embryonic growth retardation ( J:106510 )

• severely affected embryos show growth retardation at E8.5 and die before E10.5

• almost all of the rest of the embryos show mild growth retardation and die before E14.5

muscle

increased vasodilation ( J:106510 )

• severely affected embryos have dilated blood vessels especially around the sinus venosus

integument

blistering ( J:106510 )

• some embryos with intracranial hemorrhaging develop blisters on the surface of the head at E12.5

cellular

impaired basement membrane formation ( J:106510 )

• type IV collagen is seen inside the cells and in the basement membrane rather than just in the basement membrane

• the basement membrane of the neural tube is present but discontinuous and fragmented

• the basement membranes of vascular endothelial cells are absent or sometimes replaced with amorphous material