Phenotypes associated with this allele

• Allele Symbol: Gja1^{tm6.1(Gjb3)Kwi}
• Allele Name: targeted mutation 6.1, Klaus Willecke
• Allele ID: MGI:3620584
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja1^tm6.1(Gjb3)Kwi/Gja1^tm6.1(Gjb3)Kwi	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:3620770

Genotype
MGI:3620770

hm1

• Allelic Composition: Gja1^{tm6.1(Gjb3)Kwi}/Gja1^{tm6.1(Gjb3)Kwi}
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:106509 )

• 50% survived at P0, 30% at P1, and none live longer than 10 days

postnatal lethality, complete penetrance ( J:106509 )

• none live longer than 10 days

growth/size/body

decreased body weight ( J:106509 )

postnatal growth retardation ( J:106509 )

• do not grow as fast as controls

cardiovascular system

abnormal heart right ventricle outflow tract morphology ( J:106509 )

• the pulmonary outlet of the heart is prominent with irregular hypertrophic trabeculation forming abnormal pouch-like spaces

heart right ventricle outflow tract stenosis ( J:106509 )

• dysmorphogenesis of the right ventricular outflow tract, with a narrowed lumen

decreased cardiac muscle contractility ( J:106509 )

• exhibit a decrease in ejection fraction at P5, indicating reduced systolic function

decreased heart rate ( J:106509 )

• mean heart rate is significantly lower at P0

prolonged P wave ( J:106509 )

• significant prolongation of the P wave

decreased QRS amplitude ( J:106509 )

prolonged QRS complex duration ( J:106509 )

• significant prolongation of QRS duration and lower QRS amplitudes

muscle

decreased cardiac muscle contractility ( J:106509 )

• exhibit a decrease in ejection fraction at P5, indicating reduced systolic function

embryo

embryo phenotype ( J:106509 )

N • do not exhibit any defects in development and architecture of the placenta