Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc18a2tm1Uhl mutation
(0 available);
any
Slc18a2 mutation
(29 available)
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mortality/aging
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• more than one-half died by the first postnatal day 1
• no abnormality was found by pathological examination in P1 homozygous mice
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• all die by postnatal 14
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Allelic Composition |
Slc18a2tm1Uhl/Slc18a2+
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Genetic Background |
involves: 129S7/SvEvBrd * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc18a2tm1Uhl mutation
(0 available);
any
Slc18a2 mutation
(29 available)
|
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behavior/neurological
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• amphetamine-induced increases in locomotion are enhanced relative to controls
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• amphetamine produces diminished behavioral reward relative to controls, as measured by conditioned place preference
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homeostasis/metabolism
cellular
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• N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration produces more than twice the dopamine cell losses
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nervous system
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• N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration produces more than twice the dopamine cell losses
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mortality/aging
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• approximately 10% of heterozygous animals die in midlife without apparent cause
(J:42811)
• ten to fifteen percent of heterozygous mice die suddenly before 6 months of age with no apparent cause
(J:57671)
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cardiovascular system
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• freely moving heterozygous mice display significantly prolonged QT intervals compared with controls, suggesting vulnerability to lethal arrhythmias
• QTc values were also prolonged in heterozygotes compared to controls
• heterozygous mutant mice displayed no significant heart rate differences from wild type mice when resting, and baseline locomotor activities did not differ between mutant and control mice
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