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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr1tm4.1Sor
targeted mutation 4.1, Philippe Soriano
MGI:3620059
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgfr1tm4.1Sor/Fgfr1tm4.1Sor involves: 129S4/SvJaeSor * C57BL/6J MGI:3620073


Genotype
MGI:3620073
hm1
Allelic
Composition		 Fgfr1tm4.1Sor/Fgfr1tm4.1Sor
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm4.1Sor mutation (0 available); any Fgfr1 mutation (219 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:105920 )
• nearly the expected ratio of homozygous knockins is found at E16.5; a number survive to adulthood

embryo
decreased embryo size ( J:105920 )
• homozygotes are smaller than littermate controls

growth/size/body
decreased embryo size ( J:105920 )
• homozygotes are smaller than littermate controls

limbs/digits/tail
abnormal digit morphology ( J:105920 )
• embryos exhibit digit 3/4 fusions TAS




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory