Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• heart weight/body weight ratio is increased to a similar extent as in single Tg(Myh6-Pik3r1/PIK3CA)BSiz mice
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growth/size/body
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• heart weight/body weight ratio is increased to a similar extent as in single Tg(Myh6-Pik3r1/PIK3CA)BSiz mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• exhibit a significant increase in heart size, with an increase in the heart weight/body weight ratio
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growth/size/body
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• exhibit a significant increase in heart size, with an increase in the heart weight/body weight ratio
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• myocytes exhibit a 19% increase in mean cell size, with both the long and short axis lengths increased
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• hearts are about 20% larger
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• heart weight/body weight ratio is increased by 18% without changes in the size of other organs or overall body weight, however show no signs of heart failure after 1 year
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• significant increase in wall thickness in both the anterior and the posterior left ventricular (LV) walls, however observe no differences in LV diastolic or systolic diameter or fractional shortening, indicating normal cardiac function
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• mice subjected to pressure overload with aortic banding exhibit protection against pressure overload, with a trend for a reduction in left ventricle end-systolic volume and greater systolic function, blunted cardiac hypertrophy, reduced left ventricle chamber dimension, and decreased fibrosis in the left ventricular wall
• however, mice exhibit a hypertrophic response to swim exercise training similar to controls
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homeostasis/metabolism
muscle
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• myocytes exhibit a 19% increase in mean cell size, with both the long and short axis lengths increased
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growth/size/body
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• hearts are about 20% larger
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• heart weight/body weight ratio is increased by 18% without changes in the size of other organs or overall body weight, however show no signs of heart failure after 1 year
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Analysis Tools