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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ryr2tm1Amks
targeted mutation 1, Andrew R Marks
MGI:3619529
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ryr2tm1Amks/Ryr2tm1Amks involves: 129S/SvEv * C57BL/6 MGI:3619717


Genotype
MGI:3619717
hm1
Allelic
Composition		 Ryr2tm1Amks/Ryr2tm1Amks
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1Amks mutation (1 available); any Ryr2 mutation (330 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal response to cardiac infarction ( J:105666 )
• homozygotes are less susceptible to myocardial infarction-induced heart failure
• in the absence of induced myocardial infarction the morphology of homozygous hearts is similar to wild-type

homeostasis/metabolism
abnormal response to cardiac infarction ( J:105666 )
• homozygotes are less susceptible to myocardial infarction-induced heart failure
• in the absence of induced myocardial infarction the morphology of homozygous hearts is similar to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory