Phenotypes associated with this allele

• Allele Symbol: Tollip^tm1Kbns
• Allele Name: targeted mutation 1, Kimberly Burns
• Allele ID: MGI:3619521
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tollip^tm1Kbns/Tollip^tm1Kbns	involves: C57BL/6	MGI:3619846

Genotype
MGI:3619846

hm1

• Allelic Composition: Tollip^tm1Kbns/Tollip^tm1Kbns
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased circulating interleukin-6 level ( J:105514 )

• IL-6 serum concentrations are reduced

decreased interleukin-6 secretion ( J:105514 )

• macrophages secrete less IL-6 after stimulation with low concentrations of IL1B or LPS; however no differences are seen with high concentrations or in susceptibility to LPS-induced septic shock

• production of IL-6 is similar to wild-type in peritoneal macrophages stimulated with poly(I-C) and the cellular composition of the spleen, thymus and bone marrow is similar to wild-type

decreased tumor necrosis factor secretion ( J:105514 )

• macrophages secrete less TNF after stimulation with low concentrations of IL1B or LPS; however no differences are seen with high concentrations or in susceptibility to LPS-induced septic shock

• production of TNF is similar to wild-type in peritoneal macrophages stimulated with poly(I-C)

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:105514 )

• IL-6 serum concentrations are reduced