Phenotypes associated with this allele

• Allele Symbol: Tg(IGL-MYC)3Hm
• Allele Name: transgene insertion 3, Herbert Morse
• Allele ID: MGI:3619458
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Shmt1^Gt(AD0236)Wtsi/Shmt1^Gt(AD0236)Wtsi Tg(IGL-MYC)3Hm/0	B6.Cg-Shmt1^Gt(AD0236)Wtsi Tg(IGL-MYC)3Hm	MGI:5426850
cx2	Ldha^a-m1Neu/Ldha^a-m1Neu Tg(IGL-MYC)3Hm/0	involves: 101/El * C3H/El * C57BL/6N	MGI:5426847
tg3	Tg(IGL-MYC)3Hm/0	C57BL/6N-Tg(IGL-MYC)3Hm/Nci	MGI:3619459

Genotype
MGI:5426850

cx1

• Allelic Composition: Shmt1^{Gt(AD0236)Wtsi}/Shmt1^{Gt(AD0236)Wtsi}; Tg(IGL-MYC)3Hm/0
• Genetic Background: B6.Cg-Shmt1^{Gt(AD0236)Wtsi} Tg(IGL-MYC)3Hm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor growth/size ( J:183477 )

• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice

Genotype
MGI:5426847

cx2

• Allelic Composition: Ldha^a-m1Neu/Ldha^a-m1Neu; Tg(IGL-MYC)3Hm/0
• Genetic Background: involves: 101/El * C3H/El * C57BL/6N

neoplasm

increased tumor growth/size ( J:183477 )

• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice

Genotype
MGI:3619459

tg3

• Allelic Composition: Tg(IGL-MYC)3Hm/0
• Genetic Background: C57BL/6N-Tg(IGL-MYC)3Hm/Nci

mortality/aging

premature death ( J:65245 )

• most mice hemizygous for the transgene die between the ages of 2 and 6 months

immune system

enlarged lymph nodes ( J:65245 )

• transgene hemizygotes develop severe lymphadenopathy, but only minimal splenomegaly

neoplasm

increased B cell derived lymphoma incidence ( J:65245 )

• hemizygous transgenics develop clonal B-lineage lymphomas; their spleens and lymph nodes contain "uniform populations of IgM⁺CD19⁺CD5^-CD23^- cells"

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:65245