Analysis Tools
behavior/neurological
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• while intrahippocampal injection of kainic acid (KA) induces recurrent seizure-type EEG activity of similar frequency and duration, unaccompanied by overt manifestation, in transgenic and wild-type mice, the transgenic mice experience a significantly greater intra-seizure spike frequency
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• transgenic mice exhibit significantly higher baseline activity levels than do wild-type mice
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• 15 of 24 transgenic mice fitted with hippocampal and/or cortical electrodes exhibited occasional seizure-like brain activity, on average once per hour, unaccompanied by convulsion or muscle twitching; this was abolished by administration of 5-iodotubercidin (ITU), an inhibitor of adenosine kinase
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nervous system
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• while intrahippocampal injection of kainic acid (KA) induces recurrent seizure-type EEG activity of similar frequency and duration, unaccompanied by overt manifestation, in transgenic and wild-type mice, the transgenic mice experience a significantly greater intra-seizure spike frequency
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• 15 of 24 transgenic mice fitted with hippocampal and/or cortical electrodes exhibited occasional seizure-like brain activity, on average once per hour, unaccompanied by convulsion or muscle twitching; this was abolished by administration of 5-iodotubercidin (ITU), an inhibitor of adenosine kinase
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• whereas hippocampi of wild-type mice 6 weeks after kainic acid injection exhibit astrogliosis and elevated astrocyte adenosine kinase activity, transgenic hippocampi show astrogliosis in the absence of a change in enzyme activiy
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• 15 of 24 transgenic mice fitted with hippocampal and/or cortical electrodes exhibited occasional seizure-like brain activity
• intrahippocampal injection of kainic acid (KA) induces recurrent seizure-type EEG activity of similar frequency and duration
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