All Phenotypes Sord<C57BL/Lia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sord^C57BL/Lia
sorbitol dehydogenase deficiency
MGI:3616090

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sord^C57BL/Lia/Sord^C57BL/Lia	C57BL/LiA	MGI:3616182
hm2	Sord^C57BL/Lia/Sord^C57BL/Lia	involves: C57BL/LiA	MGI:3836915
cx3	Gpx1^tm1Ysh/Gpx1^tm1Ysh Sord^C57BL/Lia/Sord^C57BL/Lia	involves: 129S1/Sv * 129X1/SvJ * C57BL/LiA	MGI:3836917
cx4	Akr1b1^tm1Skc/Akr1b1^tm1Skc Sord^C57BL/Lia/Sord^C57BL/Lia	involves: 129S7/SvEvBrd * C57BL/LiA	MGI:3836916
cx5	Sord^C57BL/Lia/Sord^C57BL/Lia Tg(Cryaa-AKR1B1)648Smch/0	involves: C57BL * CBA	MGI:3783853
cx6	Sord^C57BL/Lia/Sord⁺ Tg(Cryaa-AKR1B1)648Smch/0	involves: C57BL * CBA	MGI:3783858
cx7	Sord^C57BL/Lia/Sord⁺ Tg(Cryaa-AKR1B1)222Smch/0	involves: C57BL * CBA	MGI:3783861
cx8	Sord^C57BL/Lia/Sord^C57BL/Lia Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch	involves: C57BL * CBA	MGI:3783852
cx9	Sord^C57BL/Lia/Sord^C57BL/Lia Tg(Cryaa-AKR1B1)222Smch/Tg(Cryaa-AKR1B1)222Smch	involves: C57BL * CBA	MGI:3783848

Allelic Composition	Sord^C57BL/Lia/Sord^C57BL/Lia
Genetic Background	C57BL/LiA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:44612 )

• homozygous mice exhibit no obvious abnormalities in the kidney or in other physiological functions

Allelic Composition	Sord^C57BL/Lia/Sord^C57BL/Lia
Genetic Background	involves: C57BL/LiA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:142446 )

• levels of sorbitol in the lens of 2 month old mice are very high (4.18 nmol/mg nmol/mg vs. 0.17 nmol/mg for wild-type)

cataract ( J:142446 )

• 5% of mice develop cataracts around 6 months of age

• 13 months after birth, rate of cataract incidence increases

• by 17 months of age, 69% of mice have cataracts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:142446

Allelic Composition	Gpx1^tm1Ysh/Gpx1^tm1Ysh Sord^C57BL/Lia/Sord^C57BL/Lia
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/LiA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx1^tm1Ysh mutation (2 available); any Gpx1 mutation (19 available)
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:142446 )

• cataract development is accelerated in these mice compared to mice homozygote null for just one locus

• 13% of mice have cataracts at 2 months of age, 16% of mice have cataracts at 3 months of age, and 26% of mice have cataracts at 4 months of age

Allelic Composition	Akr1b1^tm1Skc/Akr1b1^tm1Skc Sord^C57BL/Lia/Sord^C57BL/Lia
Genetic Background	involves: 129S7/SvEvBrd * C57BL/LiA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akr1b1^tm1Skc mutation (0 available); any Akr1b1 mutation (27 available)
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:142446 )

N	• mice do not have the high incidence of cataracts that Sord homozygotes have

Allelic Composition	Sord^C57BL/Lia/Sord^C57BL/Lia Tg(Cryaa-AKR1B1)648Smch/0
Genetic Background	involves: C57BL * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:106642 )

• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism

abnormal homeostasis ( J:106642 )

• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development

Allelic Composition	Sord^C57BL/Lia/Sord⁺ Tg(Cryaa-AKR1B1)648Smch/0
Genetic Background	involves: C57BL * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal homeostasis ( J:106642 )

• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development

vision/eye

cataract ( J:106642 )

• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

Allelic Composition	Sord^C57BL/Lia/Sord⁺ Tg(Cryaa-AKR1B1)222Smch/0
Genetic Background	involves: C57BL * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal homeostasis ( J:106642 )

• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development

Allelic Composition	Sord^C57BL/Lia/Sord^C57BL/Lia Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch
Genetic Background	involves: C57BL * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:106642 )

• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism

abnormal homeostasis ( J:106642 )

• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development

Allelic Composition	Sord^C57BL/Lia/Sord^C57BL/Lia Tg(Cryaa-AKR1B1)222Smch/Tg(Cryaa-AKR1B1)222Smch
Genetic Background	involves: C57BL * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sord^C57BL/Lia mutation (0 available); any Sord mutation (19 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:106642 )

• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts

homeostasis/metabolism

abnormal homeostasis ( J:106642 )

• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development

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