Analysis Tools
mortality/aging
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• mutant embryos with transgene expression could not survive to E12.5 of development
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cardiovascular system
| N |
• mutant embryos expressing the transgene underwent normal trabeculae formation, whereas trabeculae degeneration occurred in homozygous mutant without the transgene expression
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• irregular yolk sac angiogenesis is observed
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• at stage E10.5, most (74%) of the mutant embryos expressing the transgene did not show hemorrhage
• the majority of mutant embryos without the transgene expression had hemorrhage at stage E10.5
• mutant embryos exhibited hemorrhage in the pericardial cavity when they further developed from E10.5 to E11.0- E11.5
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• in E11.0-11.5 mutant embryos, TUNEL-positive cells localized to the compact area, but not trabeculae of the ventricle were detected
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muscle
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• in E11.0-11.5 mutant embryos, TUNEL-positive cells localized to the compact area, but not trabeculae of the ventricle were detected
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embryo
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• irregular yolk sac angiogenesis is observed
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• aberrant neural tube development is observed
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nervous system
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• aberrant neural tube development is observed
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homeostasis/metabolism
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• at stage E10.5, most (74%) of the mutant embryos expressing the transgene did not show hemorrhage
• the majority of mutant embryos without the transgene expression had hemorrhage at stage E10.5
• mutant embryos exhibited hemorrhage in the pericardial cavity when they further developed from E10.5 to E11.0- E11.5
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cellular
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• in E11.0-11.5 mutant embryos, TUNEL-positive cells localized to the compact area, but not trabeculae of the ventricle were detected
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