Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3ctm1Sud mutation
(1 available);
any
Rab3c mutation
(21 available)
|
|
|
behavior/neurological
 |
• double knockouts do not take care of offspring well
|
mortality/aging
|
|
• less than 100% of triple knockouts survive
|
growth/size/body
|
|
• male and female triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age
|
behavior/neurological
|
|
• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)
|
mortality/aging
|
|
• quadruple knockouts are born alive and react to stimuli; pups do not have milk in their stomachs and die soon after birth due to respiratory distress
|
homeostasis/metabolism
nervous system
|
|
• synaptic response (release) in presence of high calcium is potentiated in knockout neurons compared to control
|
|
|
• repetitive stimulation of cultured quadruple knockout neurons induces strong initial facilitation; after ~5 synaptic responses, converged to similar amplitudes with controls
(J:104983)
• EPSCs recover faster in mutant neurons than in control after depletion of the pool of synaptic vesicles
(J:104983)
• EPSCs induced by action potentials are 30% smaller than in control (Rab3b,c,d triple knockout) animals; Rab3a deficient mice show no decline in EPSC indicating that lack of this isoform is not the sole reason for the decrease observed in quadruple knockouts
(J:105478)
|
|
|
• in neurons, the synaptic release probability of vesicles is reduced by 40% compared to control triple knockout neurons; Rab3a-deficient neurons displayed no difference in release probability from wild-type
|
|
|
• neurons show strong paired-pulse facilitation
|
respiratory system
|
|
• newborn mice exhibit shallow and irregular breathing patterns
|
|
|
• newborn mice exhibit respiratory distress and die soon after birth; if mice are placed in a high oxygen atmosphere, survival time is increased
|
mortality/aging
|
|
• only 50% of triple Rab3 knockouts with wild-type Rab3d survive
|
growth/size/body
|
|
• male triple knockouts which are deficient for Rab3a display a weight decrease at 5 weeks of age
|
behavior/neurological
|
|
• surviving triple knockouts exhibit abnormal cage behavior and are unable to mate (no details provided)
|
mortality/aging
|
|
• 50% of triple Rab3 knockouts with one copy of Rab3c survive
|
growth/size/body
|
|
• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3b display a weight decrease at 5 weeks of age
|
respiratory system
|
|
• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts
|
mortality/aging
|
|
• 50% of triple Rab3 knockouts that are heterozygous for Rab3c survive
|
growth/size/body
|
|
• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3c display a weight decrease at 5 weeks of age
|
normal phenotype
|
|
• triple knockouts are fully viable; mating and growth defects seen in other triple knockouts are rescued by presence of wild-type Rab3a allele
|
Analysis Tools