Phenotypes associated with this allele

• Allele Symbol: Ube2i^tm1.1Adej
• Allele Name: targeted mutation 1.1, Anne Dejean
• Allele ID: MGI:3614394
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube2i^tm1.1Adej/Ube2i^tm1.1Adej	involves: 129S1/Sv * BALB/c * C57BL/6	MGI:3615487
ht2	Ube2i^tm1.1Adej/Ube2i^+	involves: 129S1/Sv * BALB/c * C57BL/6	MGI:3615490

Genotype
MGI:3615487

hm1

• Allelic Composition: Ube2i^tm1.1Adej/Ube2i^tm1.1Adej
• Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:104945 )

• embryos die before E7.5 but implant before degenerating

embryo

abnormal inner cell mass apoptosis ( J:104945 )

• selective apoptosis of inner cell mass

• however, trophoblastic cells did not degenerate

abnormal inner cell mass morphology ( J:104945 )

cellular

abnormal inner cell mass apoptosis ( J:104945 )

• selective apoptosis of inner cell mass

• however, trophoblastic cells did not degenerate

Genotype
MGI:3615490

ht2

• Allelic Composition: Ube2i^tm1.1Adej/Ube2i⁺
• Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6

hematopoietic system

abnormal blood cell morphology/development ( J:104945 )

• animals have increased numbers of circulating lymphocytes and granulocytes