Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall4Gt(W097E01)Flo mutation
(0 available);
any
Sall4 mutation
(144 available)
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mortality/aging
embryo
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• expression analysis detects patterning defects prior to gastrulation including defects in patterning of the extraembryonic ectoderm by E5.5
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• primitive streak formation is visible but mesoderm fails to reach the anterior or lateral limits instead accumulating on the posterior side
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• expression analysis indicates a deficit in anterior mesendoderm
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• tetraploid rescue allows embryos to survive past gastrulation but these embryos show severe posterior axis truncations at E9.5
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• no sign of node formation at E7.5
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1tm1Jkoh mutation
(0 available);
any
Sall1 mutation
(77 available)
Sall4Gt(W097E01)Flo mutation
(0 available);
any
Sall4 mutation
(144 available)
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mortality/aging
embryo
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• general growth retardation is seen at E10.5
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• full penetrance of neural tube defects
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nervous system
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• full penetrance of neural tube defects
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growth/size/body
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• general growth retardation is seen at E10.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation
(0 available);
any
Sall2 mutation
(51 available)
Sall4Gt(W097E01)Flo mutation
(0 available);
any
Sall4 mutation
(144 available)
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nervous system
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• partial penetrance of neural tube defects
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embryo
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• partial penetrance of neural tube defects
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mortality/aging
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1tm1Jkoh mutation
(0 available);
any
Sall1 mutation
(77 available)
Sall4Gt(W097E01)Flo mutation
(0 available);
any
Sall4 mutation
(144 available)
|
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mortality/aging
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• only 4 of 79 offspring of heterozygous crosses were compound heterozygotes
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nervous system
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• partial penetrance of neural tube defects
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embryo
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• partial penetrance of neural tube defects
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Sall4Gt(W097E01)Flo mutation
(0 available);
any
Sall4 mutation
(144 available)
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mortality/aging
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• absent at weaning possibly indicating embryonic lethality
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embryo
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• expression analysis indicates impaired mesoderm development
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• a gap in T expression is seen in the anterior primitive streak between E7.5 and E7.75 in the area where cells fate mapped to give rise to paraxial mesoderm are found
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growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Jkoh mutation
(0 available);
any
Sall2 mutation
(51 available)
Sall4Gt(W097E01)Flo mutation
(0 available);
any
Sall4 mutation
(144 available)
|
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nervous system
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• increase in the number of apoptotic cells at the 9 to 13 somite stage
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• full penetrance of neural tube defects
• at E9.5 the forebrain and midbrain neural folds are not fused
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embryo
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• at the 11 somite stage elevation of the neural folds in the cephalic region is reduced and distance between the tips is increased compared to controls
• at the 13 somite stage bending of the neural folds is similar to the 11 somite stage and the tips are far apart
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• full penetrance of neural tube defects
• at E9.5 the forebrain and midbrain neural folds are not fused
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mortality/aging
cellular
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• increase in the number of apoptotic cells at the 9 to 13 somite stage
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