Phenotypes associated with this allele

• Allele Symbol: Vps54^{Gt(RRI497)Byg}
• Allele Name: gene trap RRI497, BayGenomics
• Allele ID: MGI:3613397
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps54^Gt(RRI497)Byg/Vps54^Gt(RRI497)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3613574
ht2	Vps54^Gt(RRI497)Byg/Vps54^wr	involves: 129P2/OlaHsd * C57BL/6J	MGI:3613575

Genotype
MGI:3613574

hm1

• Allelic Composition: Vps54^{Gt(RRI497)Byg}/Vps54^{Gt(RRI497)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:104824 )

• embryos normal between E8.5 and E10.5

• no homozygous embryos from E12.5 onward

nervous system

absent dorsal root ganglion ( J:104824 )

• nearly completely absent at E11.5

decreased spinal cord size ( J:104824 )

• underdeveloped at E11.5

cardiovascular system

abnormal myocardial fiber morphology ( J:104824 )

• atrial and ventricular myocardium severely hypoplastic

embryo

embryonic growth retardation ( J:104824 )

• at E11.5

muscle

abnormal myocardial fiber morphology ( J:104824 )

• atrial and ventricular myocardium severely hypoplastic

growth/size/body

embryonic growth retardation ( J:104824 )

• at E11.5

Genotype
MGI:3613575

ht2

• Allelic Composition: Vps54^{Gt(RRI497)Byg}/Vps54^wr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

growth/size/body

decreased body weight ( J:104824 )

behavior/neurological

decreased grip strength ( J:104824 )

• reduced