Analysis Tools
mortality/aging
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• all mice that survive past weaning die by 17 weeks of age from cancer
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• only 8.3% (9 of 109) of pups at birth are double mutants and significant loss of these mice is seen at E16 but not at E10
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neoplasm
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• all double mutants develop cancer with a variety of tumor types
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• non-T/non-B cell derived lymphoma is also seen
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• most common type of tumor
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embryo
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• at E10 and E16, many embryos appear smaller than control littermates
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endocrine/exocrine glands
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• pituitary hyperplasia was seen in 1 mouse
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• most common type of tumor
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growth/size/body
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• at E10 and E16, many embryos appear smaller than control littermates
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• at E16
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nervous system
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• pituitary hyperplasia was seen in 1 mouse
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immune system
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• most common type of tumor
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hematopoietic system
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• most common type of tumor
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