Phenotypes associated with this allele

• Allele Symbol: TgTn(sb-T2/Onc2)6070Njen
• Allele Name: transgenic transposon concatemer 6070, Nancy A Jenkins
• Allele ID: MGI:3613048
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aicda^tm1(cre)Mnz/Aicda^+ Gt(ROSA)26Sor^tm2(sb11)Njen/Gt(ROSA)26Sor^+ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:4367198
cn2	Gt(ROSA)26Sor^tm2(sb11)Njen/Gt(ROSA)26Sor^+ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:4367197
cn3	Gt(ROSA)26Sor^tm2.1(sb11)Njen/Gt(ROSA)26Sor^+ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:4367199
cn4	Gt(ROSA)26Sor^tm1(sb11)Njen/Gt(ROSA)26Sor^+ TgTn(sb-T2/Onc2)6070Njen/0	involves: C3H * C57BL/6	MGI:3613060

Genotype
MGI:4367198

cn1

• Allelic Composition: Aicda^tm1(cre)Mnz/Aicda⁺; Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc2)6070Njen/0
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice

neoplasm

increased tumor incidence ( J:153656 )

• greater than 90% of moribund mice develop tumors with an average latency of 46 weeks

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

increased medulloblastoma incidence ( J:153656 )

• in one mouse

increased hemolymphoid system tumor incidence ( J:153656 )

• mice develop hematopoietic tumors including B cell, T cell, and myeloid tumors unlike Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice that do not develop tumors

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

increased leukemia incidence ( J:153656 )

• 2 myeloid leukemia tumors develop

increased B cell derived lymphoma incidence ( J:153656 )

• mice develop B cell lymphomas including diffuse large cell lymphomas and follicular lymphomas

• one mouse developed pre-B lymphoma

increased follicular lymphoma incidence ( J:153656 )

integument

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

nervous system

increased medulloblastoma incidence ( J:153656 )

• in one mouse

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

Genotype
MGI:4367197

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc2)6070Njen/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

immune system

increased susceptibility to infection ( J:153656 )

• 2 mice develop urinary tract infections

liver/biliary system

liver cirrhosis ( J:153656 )

• in one mouse

muscle

muscle degeneration ( J:153656 )

• one mouse exhibited myocyte degeneration

integument

abnormal skin condition ( J:153656 )

• one mouse exhibited skin irritation

Genotype
MGI:4367199

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm2.1(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc2)6070Njen/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen and Gt(ROSA)26Sor^{tm2(sb11)Njen} Aicda^tm1(cre)Mnz TgTn(sb-T2/Onc2)6070Njen mice

neoplasm

increased hemolymphoid system tumor incidence ( J:153656 )

• mice develop hematopoietic tumors including T cell and erythoid tumors

• tumor latency is 59 days

increased T cell derived lymphoma incidence ( J:153656 )

• 67% of tumors are T cell lymphomas

increased leukemia incidence ( J:153656 )

• one mouse exhibited erythroid leukemia

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153656 )

• 67% of tumors are T cell lymphomas

Genotype
MGI:3613060

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm1(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc2)6070Njen/0
• Genetic Background: involves: C3H * C57BL/6

mortality/aging

premature death ( J:102234 )

• all mice that survive past weaning die by 17 weeks of age from cancer

lethality throughout fetal growth and development, incomplete penetrance ( J:102234 )

• only 12.5% (17 of 136) of pups at birth are double mutants and significant loss of these mice is seen at E16 but not at E10

neoplasm

increased tumor incidence ( J:102234 )

• all double mutants develop cancer with a variety of tumor types

increased lymphoma incidence ( J:102234 )

• non-T/non-B cell derived lymphoma is also seen

increased T cell derived lymphoma incidence ( J:102234 )

• most common type of tumor

increased B cell derived lymphoma incidence ( J:102234 )

increased medulloblastoma incidence ( J:102234 )

• some mice develop medulloblastomas

embryo

decreased embryo size ( J:102234 )

• at E10 and E16, many embryos appear smaller than control littermates

digestive/alimentary system

abnormal duodenum morphology ( J:102234 )

• hyperplasia of the duodenum was seen in 2 mice

growth/size/body

decreased embryo size ( J:102234 )

• at E10 and E16, many embryos appear smaller than control littermates

decreased fetal size ( J:102234 )

• at E16

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:102234 )

• most common type of tumor

nervous system

increased medulloblastoma incidence ( J:102234 )

• some mice develop medulloblastomas