Phenotypes associated with this allele

• Allele Symbol: TgTn(sb-T2/Onc2)6057Njen
• Allele Name: transgenic transposon concatemer 6057, Nancy A Jenkins
• Allele ID: MGI:3613045
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(sb11)Njen/Gt(ROSA)26Sor^+ TgTn(sb-T2/Onc2)6057Njen/0	involves: C3H * C57BL/6	MGI:3613059

Genotype
MGI:3613059

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(sb11)Njen}/Gt(ROSA)26Sor⁺; TgTn(sb-T2/Onc2)6057Njen/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:102234 )

• all mice that survive past weaning die by 17 weeks of age from cancer

lethality throughout fetal growth and development, incomplete penetrance ( J:102234 )

• only 5.6% (5 of 89) of pups at birth are double mutants and significant loss of these mice is seen at E16 but not at E10

neoplasm

increased tumor incidence ( J:102234 )

• all double mutants develop cancer with a variety of tumor types

increased lymphoma incidence ( J:102234 )

• non-T/non-B cell derived lymphoma is also seen

increased T cell derived lymphoma incidence ( J:102234 )

• most common type of tumor

increased B cell derived lymphoma incidence ( J:102234 )

increased medulloblastoma incidence ( J:102234 )

• some mice develop medulloblastomas

embryo

decreased embryo size ( J:102234 )

• at E10 and E16, many embryos appear smaller than control littermates

growth/size/body

decreased embryo size ( J:102234 )

• at E10 and E16, many embryos appear smaller than control littermates

decreased fetal size ( J:102234 )

• at E16

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:102234 )

• most common type of tumor

nervous system

increased medulloblastoma incidence ( J:102234 )

• some mice develop medulloblastomas