All Phenotypes Cdx4<tm1.1Jdes> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdx1^tm1Pgr/Cdx1^tm1Pgr Cdx4^tm1.1Jdes/Y	involves: 129 * C57BL/6 * CBA * FVB	MGI:3613764
cx2	Cdx2^tm1Fbe/Cdx2⁺ Cdx4^tm1.1Jdes/Y	involves: 129 * C57BL/6 * CBA * FVB	MGI:3613767
cx3	Cdx2^tm1Fbe/Cdx2⁺ Cdx4^tm1.1Jdes/Cdx4⁺	involves: 129 * C57BL/6 * CBA * FVB	MGI:3613771
ot4	Cdx4^tm1.1Jdes/Y	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB	MGI:3613762

Allelic Composition	Cdx1^tm1Pgr/Cdx1^tm1Pgr Cdx4^tm1.1Jdes/Y
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1^tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)
Cdx4^tm1.1Jdes mutation (0 available); any Cdx4 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased rib number ( J:104372 )

• thoracic to cervical transformation of V8, with the consequent loss of one rib

thoracic vertebral transformation ( J:104372 )

• 5 of 7 have their first rib on the 9th vertebrae (V9) instead of on V8 (thoracic to cervical transformation of V8, with the consequent loss of one rib), with 3 of 5 exhibiting this transformation bilaterally

• 5 of 7 have the 8th rib pair attached to the sternum bilaterally, indicating anterior transformation at the level of V15

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:104372 )

• die shortly after E10.5

growth/size/body

embryonic growth retardation ( J:104372 )

• exhibit developmental retardation at E10.5

embryo

sirenomelia ( J:104372 )

• truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud

embryonic growth retardation ( J:104372 )

• exhibit developmental retardation at E10.5

abnormal allantois morphology ( J:104372 )

• allantoic endothelial cells often exhibit, to a variable extent, a poorer degree of primary vessel organization around the time of chorioallantoic fusion

abnormal placenta morphology ( J:104372 )

abnormal placenta vasculature ( J:104372 )

• at E10.5, maternal blood pools and embryonic blood vessels are widely separated

absent placenta hemotrichorial membrane ( J:104372 )

• the hemotrichorial membrane is almost completely absent

abnormal placenta labyrinth morphology ( J:104372 )

• all embryos that do undergo chorioallantoic fusion display deficient placental labyrinth development at E10.5

• fail to properly extend the allantoic vascular network into the chorionic ectoderm and do not develop a functional placental labyrinth

failure of chorioallantoic fusion ( J:104372 )

• allantois of 7 of 35 mutants has not fused with the chorion at E9.5

skeleton

increased rib number ( J:104372 )

• have 14 ribs due to the partial or complete bilateral rib attachment to V21

vertebral transformation ( J:104372 )

thoracic vertebral transformation ( J:104372 )

• 4 of 4 have the 8th pair of ribs attached to the sternum, indicating anterior transformation at the level of V15

lumbar vertebral transformation ( J:104372 )

• 4 of 4 have a partial or complete rib attached to V21 bilaterally, at the position normally corresponding to the first lumbar vertebrae

homeostasis/metabolism

edema ( J:104372 )

• thoracic edema at E10.5

limbs/digits/tail

sirenomelia ( J:104372 )

• truncation of embryonic structures posterior to the hindlimbs that results in a more anteriorly located tail bud

cardiovascular system

abnormal placenta vasculature ( J:104372 )

• at E10.5, maternal blood pools and embryonic blood vessels are widely separated

Allelic Composition	Cdx2^tm1Fbe/Cdx2⁺ Cdx4^tm1.1Jdes/Cdx4⁺
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx2^tm1Fbe mutation (0 available); any Cdx2 mutation (22 available)
Cdx4^tm1.1Jdes mutation (0 available); any Cdx4 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal placenta labyrinth morphology ( J:104372 )

• 2 of 11 embryos that do undergo normal chorioallantoic fusion display deficient placental labyrinth development at E10.5

failure of chorioallantoic fusion ( J:104372 )

• allantois of 2 of 28 mutants has not fused with the chorion at E9.5

Allelic Composition	Cdx4^tm1.1Jdes/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx4^tm1.1Jdes mutation (0 available); any Cdx4 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

thoracic vertebral transformation ( J:104372 )

• 1 of 8 have the eighth rib pair attached to the sternum, indicating a very mild anterior transformation at the level of V15 with extremely low penetrance, otherwise mice are healthy and appear normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23