All Phenotypes Wnt3a<tm2Eag> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt3a^tm2Eag
targeted mutation 2, Elizabeth A Grove
MGI:3612796

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Emx1^tm1(cre)Krj/Emx1⁺ Wnt3a^tm2Eag/Wnt3a⁺	involves: 129S2/SvPas	MGI:3616432
cn2	Tg(Otx1-cre)1Eag/0 Wnt3a^tm2Eag/Wnt3a⁺	Not Specified	MGI:3616434

Allelic Composition	Emx1^tm1(cre)Krj/Emx1⁺ Wnt3a^tm2Eag/Wnt3a⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (30 available)
Wnt3a^tm2Eag mutation (0 available); any Wnt3a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:104373 )

• mice die shortly after birth

craniofacial

short mandible ( J:104373 )

• lower jaw is shorter than normal

nervous system

absent Cajal-Retzius cell ( J:104373 )

• at E12.5, the neocortical zone shows a near complete absence of Cajal-Retzius cells

• at !3.5 and 15.5. the band of Cajal-Retzius cells along the marginal zone of the cortex is absent

absent choroid plexus ( J:104373 )

• at E12.5, the choroid plexus is almost completely absent

abnormal cerebral cortex morphology ( J:104373 )

• at E10, the cortical hem is almost completely ablated

• the caudomedial cortex is highly disorganized and shrunken; however, at E18.5, the layers of the rostral cortex are correctly ordered

skeleton

short mandible ( J:104373 )

• lower jaw is shorter than normal

behavior/neurological

abnormal suckling behavior ( J:104373 )

• newborn mice are unable to suckle

growth/size/body

short mandible ( J:104373 )

• lower jaw is shorter than normal

Allelic Composition	Tg(Otx1-cre)1Eag/0 Wnt3a^tm2Eag/Wnt3a⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Otx1-cre)1Eag mutation (0 available)
Wnt3a^tm2Eag mutation (0 available); any Wnt3a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:104373 )

• numbers of Cajal-Retzius cells in neocortical layer are greatly reduced and remaining cells are dispersed

decreased Cajal-Retzius cell number ( J:104373 )

• numbers of Cajal-Retzius cells in neocortical layer are greatly reduced

abnormal cerebral cortex morphology ( J:104373 )

• cortical hem is present, but smaller than normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24