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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptafrtm1Eit
targeted mutation 1, Elaine I Tuomanen
MGI:3612592
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptafrtm1Eit/Ptafrtm1Eit involves: C57BL/6 MGI:3616175


Genotype
MGI:3616175
hm1
Allelic
Composition		 Ptafrtm1Eit/Ptafrtm1Eit
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptafrtm1Eit mutation (0 available); any Ptafr mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood-brain barrier function ( J:104293 )
• null mutants infected with bacteria show a significantly increased resistance to bacterial translocation
abnormal vascular endothelial cell physiology ( J:104293 )
• bacterial translocation into the blood and from blood into cerebrospinal fluid is delayed

nervous system
abnormal blood-brain barrier function ( J:104293 )
• null mutants infected with bacteria show a significantly increased resistance to bacterial translocation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory